Kyle M. Malecki

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BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide and its progressive form, steatohepatitis, will be the leading indication for liver transplant by 2020. While risk factors for steatohepatitis have been identified, little work has been performed to identify factors protective against NAFLD development.(More)
OBJECTIVE The purpose of this study was to investigate objective semiautomated measurement of liver surface nodularity on MDCT for prediction of underlying hepatic fibrosis (stages F0-F4). MATERIALS AND METHODS Contrast-enhanced abdominal MDCT scans were assessed with an independently validated semiautomated surface nodularity tool. A series of 10 or more(More)
To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis. Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374; F1 = 48; F2 = 40; F3 = 65; F4 = 97). The liver segmental volume ratio(More)
To evaluate CT texture analysis (CTTA) for staging of hepatic fibrosis (stages F0–F4) Quantitative texture analysis (QTA) of the liver was performed on abdominal MDCT scans using commercially available software (TexRAD), which uses a filtration-histogram statistic-based technique. Single-slice ROI measurements of the total liver, Couinaud segments IV-VIII,(More)
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