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The mating pathway in Saccharomyces cerevisiae has been the focus of considerable research effort, yet many quantitative aspects of its regulation still remain unknown. Using an integrated approach involving experiments in microfluidic chips and computational modelling, we studied gene expression and phenotypic changes associated with the mating response(More)
We describe the principles of design and the architecture of planar microfluidic networks producing concentration gradients with the shape of any given monotonic function. Each microfluidic network is fed by two separate source solutions and delivers to its outlet a set of N solutions that all differ in concentration. Inside the network, the source(More)
Colonies of bacterial cells can display complex collective dynamics, frequently culminating in the formation of biofilms and other ordered super-structures. Recent studies suggest that to cope with local environmental challenges, bacterial cells can actively seek out small chambers or cavities and assemble there, engaging in quorum sensing behavior. By(More)
Recent growth in microfluidic technology is, to a large extent, driven by soft lithography, a high-throughput fabrication technique where polymer materials, such as poly͑dimethyl͒ siloxane ͑PDMS͒, are molded to form microscopic channel networks. Nevertheless, the channel architectures that can be obtained by molding are limited. We address this limitation(More)
The taxonomy of treeshrews (Order Scandentia) has long been complicated by ambiguous morphological species boundaries, and the treeshrews of the Palawan faunal region of the Philippines are no exception. Four named forms in the genus Tupaia Raffles, 1821, have been described from four island groups based on subtle qualitative morphological characters, and(More)
A microfluidic device that operates as a set of two adaptive cylindrical lenses focusing light along two orthogonal axes is designed, fabricated and characterized. The device is made out of a silicon elastomer, polydimethylsiloxane, using soft lithography, and consists of a few chambers separated by flexible membranes and filled with liquids of different(More)
The Philippine Islands are one of the most biologically diverse archipelagoes in the world. Current taxonomy, however, may underestimate levels of avian diversity and endemism in these islands. Although species limits can be difficult to determine among allopatric populations, quantitative methods for comparing phenotypic and genotypic data can provide(More)
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