Kyle J. Stearns

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Partial reversibility is an underexplored avenue for balancing high computational throughput and low power dissipation in nanocomputing systems. In this work we study the throughput-dissipation tradeoff in a partially reversible 32bit MIPS ALU implemented in quantum cellular automata and clocked via the “pipelined Bennett clocking” strategy recently(More)
Although serine proteases are found ubiquitously in both eukaryotes and prokaryotes, and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure. The backbone dynamics of the coagulation serine protease, apo-thrombin (S195M-thrombin), were compared to the substrate-bound form (PPACK-thrombin). R1, R2, 15N-{1H}NOEs,(More)
The potential of nanomelic chondrocytes to synthesize chondroitin sulfate was investigated by providing the mutant cells with p-nitrophenyl-beta-D-xyloside, a compound which acts as an artificial acceptor for glycosaminoglycan synthesis. Under these conditions the synthesis of chondroitin sulfate in nanomelic and normal chondrocytes is comparable. The(More)
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