Kyle I. S. Harrington

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  • S McNeil, C Zeng, +5 authors G S Stein
  • 1999
Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear matrix-targeting signal that directs the AML1 protein to(More)
We investigate the Belousov-Zhabotinsky (BZ) reaction in an attempt to establish a basis for computation using chemical oscillators coupled via inhibition. The system consists of BZ droplets suspended in oil. Interdrop coupling is governed by the non-polar communicator of inhibition, Br2. We consider a linear arrangement of three droplets to be a NOR gate,(More)
Vascular network density determines the amount of oxygen and nutrients delivered to host tissues, but how the vast diversity of densities is generated is unknown. Reiterations of endothelial-tip-cell selection, sprout extension and anastomosis are the basis for vascular network generation, a process governed by the VEGF/Notch feedback loop. Here, we find(More)
Banzhaf and Yamamoto introduce artificial chemistries (ACs) in the original spirit of artificial life: ''life as it could be,'' where ACs focus on chemical reactions and dynamics as they could be. The field of AC brings together a large number of disciplines from computer science to chemistry to social sciences. The book does an excellent job at balancing(More)
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