Kyle D. Ross

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Rapid eye movement sleep deprivation (REMd) is a potent stressor in the rat. Behavioral abnormalities are among the earliest overt symptoms of REMd, the mechanisms for which remain largely unknown. The phenomena of hyperphagia and weight loss that are associated with REMd may contribute to its later morbidity; however, little is known about the onset of(More)
The precise distribution of the dopamine type D2 receptor has been mapped for the first time in rat brain using an antibody to D2 receptor protein. Polyclonal antisera were collected from rabbits inoculated with an undecapeptide identical to residues 24-34 of the D2 protein sequence. Rat brain slices, 40 microns in thickness, were incubated with either(More)
A new mutant derived from the Zucker rat strain called stargazer (homozygous stg/stg) displays abnormal behavior that is characterized by pronounced arching of the neck ("stargazing"), rapid circling, and conspicuous hyperactivity. Results of serologic assays performed by two independent diagnostic laboratories have indicated that the abnormal behavior in(More)
REM sleep deprivation (RSD) of rats results in facilitation of dopaminergic behavior and an increase in striatal D2 receptor density. To determine whether RSD results in changes in D2 receptor in other brain regions, receptor affinity (Kd) and density (Bmax) were measured in the anteromediofrontal (AM), cingulate (CN), and sulcal cortex (SL) in four groups(More)
Generic libraries, such as the C++ Standard Template Library (STL), provide flexible, high-performance algorithms and datatypes, along with functional specifications and performance guarantees. It is left as a nontrivial task to the library user to choose appropriate algorithms and data types for a particular problem. In the present paper, we describe an(More)
Rats consuming a high-protein diet (HP; 50% casein) have increased locomotor activity, are hyper-responsive to nociceptive stimuli, and have increased basal arousal levels, as compared to rats maintained on a normal-protein diet (NP; 20% casein). The present study was performed to determine whether animals on the HP diet display deficits in learning,(More)
L-Tyrosine is a non-essential amino acid that is produced as an intermediary metabolite in the conversion of phenylalanine to 3,4-dihyroxyphenylalanine (DOPA), and is a precursor of the neurotransmitter dopamine. In previous studies, tyrosine pretreatment was shown to protect against the neurochemical and behavioral deficits of acute stress caused by tail(More)
Using the water tank procedure, we have examined the effects of rapid eye movement (REM) sleep deprivation and associated stress on the properties of striatal dopaminergic system. While stress decreased the number of D1 and D2 dopamine receptors, a combination of REM sleep deprivation attenuated the decrease. The ratio of D1 to D2 densities, however,(More)
The stargazer rat is an autosomal recessive mutant (homozygous stg/stg) that displays abnormal behavior, including profound hyperactivity. Heterozygous stg/+ littermates are unaffected (i.e., are nonmutants), and display normal spontaneous behaviors. Abnormal spontaneous behavior in the stargazer rats suggest that they may be more responsive than their(More)
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