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Mounting evidence suggests that protein methyltransferases (PMTs), which catalyze methylation of histone and nonhistone proteins, play a crucial role in diverse biological processes and human diseases. In particular, PMTs have been recognized as major players in regulating gene expression and chromatin state. PMTs are divided into two categories: protein(More)
Posttranslational modifications of histone proteins represent a fundamental means to define distinctive epigenetic states and regulate gene expression during development and differentiation. Aberrations in various chromatin-modulation pathways are commonly used by tumors to initiate and maintain oncogenesis, including lymphomagenesis. Recently, increasing(More)
Post-translational modifications of histone proteins represent a fundamental meansto define distinctive epigenetic states and regulate gene expression during development and differentiation. Aberrationsin various chromatin modulation pathways are commonly used by tumors to initiate and maintain oncogenesis, including lymphomagenesis. Recently,increasing(More)
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