Learn More
Pathophysiology of the temporomandibular joint (TMJ) disc is central to many orofacial disorders; however, mechanical characterization of this tissue is incomplete. In this study, we identified surface-regional mechanical variations in the porcine TMJ disc under unconfined compression. The intermediate zone, posterior, anterior, lateral, and medial regions(More)
The temporomandibular joint (TMJ) disc is a central element in several TMJ disorders. Tissue-engineered TMJ disc replacements may alleviate discomfort associated with TMJ disorders; however, prior to developing a replacement, a thorough understanding of the native disc must be attained. Toward this end, we developed an unconfined compression, incremental(More)
OBJECTIVE In mice with Col9a1 gene inactivation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely. The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies. METHODS Col9a1(-/-) and wild-type mice were investigated for reflexes,(More)
Patients with osteoarthritis (OA) primarily seek treatment due to pain and disability, yet the primary endpoints for rodent OA models tend to be histological measures of joint destruction. The discrepancy between clinical and preclinical evaluations is problematic, given that radiographic evidence of OA in humans does not always correlate to the severity of(More)
INTRODUCTION Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both preclinical OA models and OA patients. The objective of this study is to describe spatiotemporal and ground reaction force changes in a rat medial meniscus transection (MMT)(More)
OBJECTIVE Implantation of synthetic temporomandibular joint (TMJ) disc replacements aimed to alleviate pain and restore functional losses caused by TMJ disorders. Unfortunately, these synthetic replacements have been largely unsuccessful and in some instances have incited severe immune responses. Tissue engineering, however, may provide viable TMJ disc(More)
Gait and behavior in an IL1β-mediated arthritis model and effects of IL1 antagonism Abstract (250 Word Limit) Objective: Interleukin-1 beta (IL1β) is a pro-inflammatory cytokine that mediates arthritic pathologies. Our objective was to evaluate pain and limb dysfunction resulting from IL1β over-expression in the rat knee and investigate the ability of local(More)
INTRODUCTION Tumor necrosis factor-α (TNFα) has received significant attention as a mediator of lumbar radiculopathy, with interest in TNF antagonism to treat radiculopathy. Prior studies have demonstrated that TNF antagonists can attenuate heightened nociception resulting from lumbar radiculopathy in the preclinical model. Less is known about the potential(More)
GOAL This paper investigates the practicality of using a small, permanent magnet to capture magnetic particles out of high-viscosity biological fluids, such as synovial fluid. METHODS Numerical simulations are used to predict the trajectory of magnetic particles toward the permanent magnet. The simulations are used to determine a "collection volume" with(More)
INTRODUCTION After transection of the medial collateral ligament and medial meniscus (MCLT + MMT) in the rat, focal cartilage lesions develop over 4-6 weeks; however, sham surgery (MCLT alone) does not result in cartilage damage over a similar period. Thus, comparison of MCLT + MMT with the MCLT sham group offers an opportunity to investigate behavioral(More)