• Publications
  • Influence
Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy.
To prepare a water-insoluble camptothecin (CPT) delivery carrier, hydrophobically modified glycol chitosan (HGC) nanoparticles were constructed by chemical conjugation of hydrophobic 5beta-cholanicExpand
  • 347
  • 9
Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance.
As an alternative to cell specific cancer targeting strategies (which are often afflicted with the heterogeneity of cancer cells as with most biological systems), a novel polymeric micelle constituteExpand
  • 293
  • 7
  • PDF
Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice.
We reported the development of new nanoscale drug carriers, chitosan-based nanoparticles (CNPs) that can be used for photodynamic therapy. These carriers could encapsulate a photosensitizer,Expand
  • 124
  • 6
Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring.
  • K. Kim, J. Kim, +11 authors I. C. Kwon
  • Medicine
  • Journal of controlled release : official journal…
  • 1 September 2010
Theragnostic multifunctional nanoparticles hold great promise in simultaneous diagnosis of disease, targeted drug delivery with minimal toxicity, and monitoring of treatment. One of the currentExpand
  • 269
  • 5
  • PDF
Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy.
The main objective of this study was to develop and characterize a pH-responsive and biodegradable polymeric micelle as a tumor-targeting drug delivery system. The pH-responsive block copolymer wasExpand
  • 235
  • 5
  • PDF
PLGA microsphere construct coated with TGF-beta 3 loaded nanoparticles for neocartilage formation.
Polymeric microsphere system has been widely used in tissue-regeneration matrix and drug delivery systems. To apply these biomaterials as novel cell supporting matrix for stem cell delivery, we haveExpand
  • 47
  • 5
New Generation of Multifunctional Nanoparticles for Cancer Imaging and Therapy
Advances in nanotechnology have contributed to the development of novel nanoparticles that enable the tumor-specific delivery of imaging probes and therapeutic agents in cancer imaging and therapy.Expand
  • 341
  • 4
A near-infrared-fluorescence-quenched gold-nanoparticle imaging probe for in vivo drug screening and protease activity determination.
Nanoscale fluorescence optical imaging probes are paving the way for novel methods to sense and spot live molecular targets. Various probes have been developed, including semiconductor quantum dots,Expand
  • 288
  • 3
Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles.
To improve the in vivo tumor targeting characteristics of polymeric nanoparticles, three glycol chitosan (GC-20 kDa, GC-100 kDa, and GC-250 kDa) derivatives with different molecular weights wereExpand
  • 210
  • 3
Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo.
We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenicExpand
  • 130
  • 3