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High-quality Ca0.8Dy0.2MnO3 nano-powders were synthesized by the solution combustion process. The size of the synthesized Ca0.8Dy0.2MnO3 powders was approximately 23 nm. The green pellets were sintered at 1150-1300°C at a step size of 50°C. Sintered Ca0.8Dy0.2MnO3 bodies crystallized in the perovskite structure with an orthorhombic symmetry. The sintering(More)
As an alternative to cell specific cancer targeting strategies (which are often afflicted with the heterogeneity of cancer cells as with most biological systems), a novel polymeric micelle constitute of two block copolymers of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)-TAT (transactivator of transcription) and(More)
The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics(More)
The objective of this study was to assess whether carboxymethyl cellulose- (CMC-) based hydrogel containing BioC (biphasic calcium phosphate (BCP); tricalcium phosphate (TCP) : hydroxyapatite (Hap) = 70 : 30) and bone morphogenic protein-2 (BMP-2) led to greater bone formation than CMC-based hydrogel containing BioC without BMP-2. In order to demonstrate(More)
The aim of orthopedic and dental tissue engineering is to generate synthetic bone-graft tissue substitutes. It is generally comprised through the combination of viable cells, a scaffolding material, and sometimes the inclusion of bone morphogenic proteins. The object of this study is to develop novel bone-grafting scaffolds that enhance osteoblast activity.(More)
The objective of this study was to determine the effects on osteoblast activity of a recombinant human bone morphogenic protein (rhBMP)-2/heparin complex immobilized on a chitosan scaffold (Hep-C-rhBMP-2/chitosan) compared to a rhBMP-2-dipping chitosan (rhBMP-2/chitosan) and to a chitosan scaffold alone. Scanning electron microscopy (SEM) confirmed that the(More)
Therapeutic target for over-expressed αvβ3 integrins in angiogenic endothelial cells and tumors is one of the promising approaches for cancer imaging and therapy. In the previous study, we demonstrated that heparin–lithocholic acid functionalized with cyclic RGDyK (cRGD–HL) had potent angiogenesis inhibition and tumor regression effects. The aim of this(More)
Biphasic calcium phosphate (BCP) scaffolds have been widely used in orthopedic and dental fields as osteoconductive bone substitutes. However, BCP scaffolds are not satisfactory for the stimulation of osteogenic differentiation and maturation. To enhance osteogenic differentiation, we prepared alendronate- (ALN-) eluting BCP scaffolds. The coating of ALN on(More)
We investigate the role of hyaluronic acid (HA) on S. pneumoniae in vitro biofilm formation and evaluate gene expressions of virulence and/or biofilm related genes. Biofilms were grown in medium supplied with HA derived from capsule of Streptococcus equi. The biomasses of biofilms were detected by crystal-violet (CV) microtiter plate assay, and the(More)
Titanium (Ti) has been widely used in the dental field owing to its good biocompatibility, superior mechanical properties, and excellent corrosion resistance. However, Ti lacks the osteoconductivity and osteoinductivity required to promote mineralization. In the present study, the authors investigated whether apatite-coated Ti and rhBMP-2 treated(More)