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Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
TLDR
The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into Norovirus biology. Expand
Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses
TLDR
Three compounds possessing a common dipeptidyl residue with different warheads against viruses that belong to the supercluster have the potential to be developed as antiviral therapeutics aimed at a single virus or multiple viruses in the picornavirus-like superclusters by targeting 3Cpro or 3CLpro. Expand
Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.
TLDR
expression of replicon RNA was significantly reduced in the presence of interferon (IFN)-alpha in a dose-dependent manner in the NV replicon-bearing cells, suggesting a role for innate immunity in the control of human norovirus replication. Expand
Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells
TLDR
The availability of the MNV nonstructural polyprotein cleavage map in concert with a permissive cell culture system should facilitate studies of norovirus replication. Expand
Feline Calicivirus VP2 Is Essential for the Production of Infectious Virions
TLDR
The data indicate that VP2, a protein apparently unique to the caliciviruses, is essential for productive replication that results in the synthesis and maturation of infectious virions and that the ORF3 nucleotide sequence itself overlaps a cis-acting RNA signal at the genomic 3′ end. Expand
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
TLDR
It is found that antiviral treatment led to full recovery of cats when treatment was started at a stage of disease that would be otherwise fatal if left untreated, and results indicate that continuous virus replication is required for progression of immune-mediated inflammatory disease of FIP. Expand
Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells
TLDR
The results indicated that IFNs and ribavirin may be good therapeutic options for noroviral gastroenteritis. Expand
Role of Cholesterol Pathways in Norovirus Replication
TLDR
It is concluded that the cholesterol pathways such as LDLR expression and ACAT activity may be crucial in the replication of noroviruses in cells, which may provide potential therapeutic targets for viral infection. Expand
Norovirus Proteinase-Polymerase and Polymerase Are Both Active Forms of RNA-Dependent RNA Polymerase
TLDR
The data suggest that the norovirus ProPol is a bifunctional enzyme during virus replication, and the availability of this recombinant ProPol enzyme might prove useful in the development of antiviral drugs for control of thenoroviruses associated with acute gastroenteritis. Expand
Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1.
TLDR
A mechanism for enteric calicivirus growth dependent on bile acids, ubiquitous molecules present in the intestine at the site of the virus replication that involves the protein kinase A cell-signaling pathway and a possible down-regulation of innate immunity is proposed. Expand
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