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Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice.
TLDR
Results suggest that SFN may induce antiobesity activity by inhibiting adipogenesis through down-regulation of PPARγ and C/EBPα and by suppressing lipogenesis through activation of the AMPK pathway. Expand
Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
TLDR
Results suggest that esculetin (1), an active compound from F. rhynchophylla, inhibited early stage of adipogenic differentiation, in part, via inhibition of PPARgamma-dependent pathway. Expand
Sulforaphane Inhibits Mitotic Clonal Expansion During Adipogenesis Through Cell Cycle Arrest
TLDR
The results indicate that sulforaphane may specifically affect mitotic clonal expansion to inhibit adipocyte differentiation and may be associated with cell cycle arrest at the G0/G1 phase through upregulation of p27 expression. Expand
Anti-Obesity Effect of 6,8-Diprenylgenistein, an Isoflavonoid of Cudrania tricuspidata Fruits in High-Fat Diet-Induced Obese Mice
TLDR
The anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet-induced obese mice at the doses of 10 and 30 mg/kg for six week and the body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. Expand
Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment.
TLDR
The results suggest that the suppression of tumor formation by compound 1 in human colon cancer may occur through cell cycle arrest and apoptosis. Expand
Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis
TLDR
Tumor formation was significantly inhibited by intradermal and intraperitoneal administrations of myriocin and the decreased levels of sphingolipids in serum and liver of melanoma mice treated with myriOCin suggest that myRIocin may be accessible to tumor tissues of advanced melanoma. Expand
Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice.
TLDR
The results indicate that the antiobesity effects of GTE may be associated with activation of the AMPK pathway. Expand
Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway
Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of anExpand
Secoiridoids from the stem barks of Fraxinus rhynchophylla with pancreatic lipase inhibitory activity
TLDR
Together, F. rhynchophylla and its constituents might be beneficial to obesity and exerted inhibitory effect on pancreatic lipase in a mixed mechanism of competitive and noncompetitive manner. Expand
Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes
TLDR
Results suggest that MDGA may increase GLUT4 expression and its translocation by promoting insulin sensitivity, leading to enhanced glucose uptake. Expand
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