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To elucidate the effects of streaming flow on ultrasound contrast agent (UCA)-assisted drug delivery, streaming velocity fields from sonicated UCA microbubbles were measured using particle image velocimetry (PIV) in a blood vessel model. At the beginning of ultrasound sonication, the UCA bubbles formed clusters and translated in the direction of the(More)
An endovascular technique using a stent has been developed and successfully applied in the treatment of wide neck aneurysms. A stent can facilitate thrombosis in the aneurysm pouch while maintaining biocompatible passage of the parent artery. Insertion of the stent changes the flow characteristics inside the aneurysm pouch, which can affect the(More)
In order to study the flow dynamic changes inside an aneurysm sac due to the partial occlusion of the aneurysm neck, velocity fields were measured using a particle image velocitimeter (PIV) in in vitro aneurysm models under the physiological flow waveform. Lateral aneurysm models arising from the curved parent vessel with different occlusion ratios and(More)
We developed a new imaging probe for atherosclerotic lesion imaging by chemically conjugating an atherosclerotic plaque-homing peptide (termed the AP peptide) to hydrophobically modified glycol chitosan (HGC) nanoparticles. The AP peptide was previously discovered by using an in vivo phage display screening method. HGC nanoparticles were labeled with the(More)
In case of coil embolization of a giant or a multilobular aneurysm, it is difficult to fill an aneurysm sac completely with coils, therefore, partial blocking of an aneurysm sac is inevitable. Blood flow characteristics, which may influence embolization process of an aneurysm, are affected by the locations of coils for partially blocked aneurysms. Blood(More)
The progression of a cerebral aneurysm involves degenerative arterial wall remodeling. Various hemodynamic parameters are suspected to be major mechanical factors related to the genesis and progression of vascular diseases. Flow alterations caused by the insertion of coils and stents for interventional aneurysm treatment may affect the aneurysm embolization(More)
To study the effects of the geometrical characteristics of a framing coil on aneurysm thromboembolization efficacy, the hemodynamics in lateral aneurysms filled with coils having a different shape, orientation, and thickness were analyzed using computational fluid dynamics. The aneurysms packed with vortex and cage-shaped coils were modeled using three(More)
Endothelium plays a vital role in various vascular functions, and its dysfunction is a key underlying process closely related to diverse array of diseases such as atherosclerosis and tumor. Therefore, early detection of endothelial dysfunction at the functional or molecular level is of high importance for effective therapy. Recent advances in nanotechnology(More)
Targeting ligands to dysfunctional or activated endothelial cells overlying atherosclerotic plaques could provide tools for selective drug delivery to atherosclerotic lesions. To identify peptides selectively targeting dysfunctional endothelial cells, a phage library was screened against tumor necrosis factor-alpha (TNF-alpha) activated bovine aortic(More)
The hemodynamic changes induced by stent deployment and vascular remodeling in bifurcation aneurysms were investigated using computational fluid dynamics. The stent deployment reduced the intra-aneurysmal flow activity by decreasing the mean velocity, mean kinetic energy, mean wall shear stress, and mean vorticity. These hemodynamic parameters increased(More)