The progression of a cerebral aneurysm involves degenerative arterial wall remodeling. Various hemodynamic parameters are suspected to be major mechanical factors related to the genesis and progression of vascular diseases. Flow alterations caused by the insertion of coils and stents for interventional aneurysm treatment may affect the aneurysm embolization… (More)
To study the effects of the geometrical characteristics of a framing coil on aneurysm thromboembolization efficacy, the hemodynamics in lateral aneurysms filled with coils having a different shape, orientation, and thickness were analyzed using computational fluid dynamics. The aneurysms packed with vortex and cage-shaped coils were modeled using three… (More)
Drug delivery into neurological tissue is challenging because of the low tissue permeability. Ultrasound incorporating microbubbles has been applied to enhance drug delivery into these tissues, but the effects of a streaming flow by microbubble oscillation on drug perfusion have not been elucidated. In order to clarify the physical effects of steady… (More)
In order to elucidate particle size and wall shear effects on the selective binding of nanoparticles to vessel wall, particle binding to the wall of arterial stenosis was computationally analyzed using a transport and reaction model. The attachment rate constant was modeled as a function of shear rate and particle size. The results showed that it had a… (More)
The hemodynamic changes induced by stent deployment and vascular remodeling in bifurcation aneurysms were investigated using computational fluid dynamics. The stent deployment reduced the intra-aneurysmal flow activity by decreasing the mean velocity, mean kinetic energy, mean wall shear stress, and mean vorticity. These hemodynamic parameters increased… (More)
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Various nanoparticles have been developed as imaging probes and drug carriers, and their selectivity in binding to target cells determines the efficacy of these functionalized nanoparticles. Since target cells in different arterial segments experience different hemodynamic environments, we study the effects of wall shear rate waveforms on particle binding.… (More)
Numerical analysis was performed on the enzyme transport and the flow fields in order to predict the effectiveness of forced injection in thrombolytic therapy. The species and momentum transport equations were numerically solved for the case of uniform perfusion of enzyme into the fibrin clot, and the validity of our methods were verified. In order to… (More)