Kye Hwa Lee

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BACKGROUND Chronic widespread pain (CWP) is known as a common symptom of several organic and psychological disorders. Although medically unexplained CWP (MUE) has lots of clinical distress symptoms, there were no distinct symptoms or signs. Therefore, we conducted this study to investigate clinical distress symptoms of MUE distinct from those of medically(More)
Despite substantial premarket efforts, a significant portion of approved drugs has been withdrawn from the market for safety reasons. The deleterious impact of nonsynonymous substitutions predicted by the SIFT algorithm on structure and function of drug-related proteins was evaluated for 2504 personal genomes. Both withdrawn (n = 154) and precautionary(More)
Introduction Translational bioinformatics (TBI) is a relatively young discipline that spans a wide spectrum from data to diagnostics and therapeutics. TBI involves applying novel methods to the storage, analysis, and interpretation of a massive volume of omics data, and it bridges the gap between bench research and real-world application to human health.(More)
In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with(More)
The relationship between the number of withdrawn/restricted drugs and socioeconomic, health, and welfare indicators were investigated in a comprehensive review of drug regulation information in the United Nations (UN) countries. A total of of 362 drugs were withdrawn and 248 were restricted during 1950-2010, corresponding to rates of 12.02 ± 13.07 and 5.77(More)
BACKGROUND/AIM Extrathyroidal extension (ETE) indicates the invasiveness of primary thyroid tumor into the adjacent tissue, and its importance as a prognostic factor overrides tumor size in classifying the cancer stage. The aim of this study was to determine the molecular basis of ETE in papillary thyroid carcinomas (PTCs). MATERIALS AND METHODS We(More)
Objective We propose 2 Medical Dictionary for Regulatory Activities-enabled pharmacovigilance algorithms, MetaLAB and MetaNurse, powered by a per-year meta-analysis technique and improved subject sampling strategy. Matrials and methods This study developed 2 novel algorithms, MetaLAB for laboratory abnormalities and MetaNurse for standard nursing(More)
OBJECTIVES Through telehealth, medical services have expanded beyond spatial boundaries and are now available in living spaces outside of hospitals. It can also contribute to patient medical knowledge improvement because patients can access their hospital records and data from home. However, concepts of telehealth are rather vague in Korea. METHODS We(More)
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