Kwong-Sak Leung

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Inductive Logic Programming (ILP) integrates the techniques from traditional machine learning and logic programming to construct logic programs from training examples. Most existing systems employ greedy search strategies which may trap the systems in a local maxima. This paper describes a system, called the Genetic Logic Programming System (GLPS), that(More)
The self-organizing map (SOM) has been successfully employed to handle the Euclidean traveling salesman problem (TSP). By incorporating its neighborhood preserving property and the convex-hull property of the TSP, we introduce a new SOM-like neural network, called the expanding SOM (ESOM). In each learning iteration, the ESOM draws the excited neurons close(More)
In this paper, we propose a probabilistic ruledriven adaptive model (PRAM) for parameter adaptation and a repelling approach for diversity maintenance in genetic algorithms. PRAM uses three parameter values and a set of greedy rules to adapt the value of the control parameters automatically. The repelling algorithm is proposed to maintain the population(More)
Crowd sourcing is evolving as a distributed problem-solving and business production model in recent years. In crowd sourcing paradigm, tasks are distributed to networked people to complete such that a company's production cost can be greatly reduced. In 2003, Luis von Ahn and his colleagues pioneered the concept of "human computation", which utilizes human(More)
MOTIVATION Identification of transcription factor binding sites (TFBSs) plays an important role in deciphering the mechanisms of gene regulation. Recently, GAME, a Genetic Algorithm (GA)-based approach with iterative post-processing, has shown superior performance in TFBS identification. However, the basic GA in GAME is not elaborately designed, and may be(More)
We have developed a new approach (MDLEP) to learning Bayesian network structures based on the Minimum Description Length (MDL) principle and Evolutionary Programming (EP). It employs a MDL metric, which is founded on information theory, and integrates a knowledge-guided genetic operator for the optimization in the search process. In contrast, existing(More)
This correspondence introduces a multidrug cancer chemotherapy model to simulate the possible response of the tumor cells under drug administration. We formulate the model as an optimal control problem. The algorithm in this correspondence optimizes the multidrug cancer chemotherapy schedule. The objective is to minimize the tumor size under a set of(More)
BACKGROUND We aimed to investigate the characteristics of hepatitis B virus (HBV) genotype C subgroups in Hong Kong and their relationship with HBV genotype C in other parts of Asia. METHODS Full-genome nucleotide sequences of 49 HBV genotype C isolates from Chinese patients with chronic hepatitis B were compared with the sequences of 69 HBV genotype C(More)