• Publications
  • Influence
Hydrogen Peroxide Activates p70S6k Signaling Pathway*
We investigated a possible role of reactive oxygen species (ROS) in p70S6k activation, which plays an important role in the progression of cells from G0/G1 to S phase of the cell cycle byExpand
  • 144
  • 10
  • PDF
Actin Filaments in Mature Guard Cells Are Radially Distributed and Involved in Stomatal Movement
Stomatal movements, which regulate gas exchange in plants, involve pronounced changes in the shape and volume of the guard cell. To test whether the changes are regulated by actin filaments, weExpand
  • 97
  • 7
Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NF-kappaB activation.
  • K. Kim, Y. Kwon, +6 authors Y. Kim
  • Medicine, Chemistry
  • Toxicology and applied pharmacology
  • 1 July 2003
Cordyceps pruinosa has been used in traditional folk medicine to treat numerous diseases. The molecular mechanism of C. pruinosa pharmacological and biochemical actions of macrophages in inflammationExpand
  • 90
  • 6
Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol.
The translocation of protein kinase C (PKC) from the cytosolic to the particulate fraction in IIC9 fibroblasts has been studied to define the functions of 1,2-diacylglycerol (DAG) derived from theExpand
  • 172
  • 5
Isolation and Characterization of Guamerin, a New Human Leukocyte Elastase Inhibitor from Hirudo nipponia(*)
A new human leukocyte elastase inhibitor was extracted and purified from a Korean native leech Hirudo nipponia. The inhibitor, called guamerin, has a molecular weight of 6,110 and shows inhibitionExpand
  • 55
  • 5
Requirement of Hydrogen Peroxide Generation in TGF-β1 Signal Transduction in Human Lung Fibroblast Cells: Involvement of Hydrogen Peroxide and Ca2+ in TGF-β1-Induced IL-6 Expression1
Stimulation of human lung fibroblast cells with TGF-β1 resulted in a transient burst of reactive oxygen species with maximal increase at 5 min after treatment. This reactive oxygen species increaseExpand
  • 132
  • 4
Cyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis inExpand
  • 65
  • 4
  • PDF
Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts
alpha-Thrombin induced a change in the cell morphology of IIC9 fibroblasts from a semiround to an elongated form, accompanied by an increase in stress fibers. Incubation of the cells withExpand
  • 163
  • 3
  • PDF
Involvement of cytosolic phospholipase A2, and the subsequent release of arachidonic acid, in signalling by rac for the generation of intracellular reactive oxygen species in rat-2 fibroblasts.
Although there have been a number of recent studies on the role of Rac in the generation of reactive oxygen species (ROS), details of the signalling pathway remain unclear. In the present study weExpand
  • 31
  • 3
  • PDF
Upon exposure to elevated growth temperatures, mammalian cells exhibit a variety of cellular responses, such as the expression of heat‐shock proteins (HSPs) and the activation of stress‐activatedExpand
  • 20
  • 2