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The membrane transferrin receptor-mediated endocytosis or internalization of the complex of transferrin bound iron and the transferrin receptor is the major route of cellular iron uptake. This efficient cellular uptake pathway has been exploited for the site-specific delivery not only of anticancer drugs and proteins, but also of therapeutic genes into(More)
Bacillus subtilis MUR1 is a novel lactic acid (LA) producing strain that has the potential for industrial production of LA due to its high productivity of LA, high yield of substrate conversion, and high final concentration of LA produced. B. subtilis MUR1 can produce 99.3 and 183.2g/l of L-LA in 12 and 52 h respectively with a 98.5% substrate conversion(More)
Ceruloplasmin (CP) is essential for brain iron homeostasis. However, its precise function in brain iron transport has not been definitely determined. In this study, we investigated the effects of soluble CP on iron influx and efflux in primary neuronal culture from the midbrain (the substantia nigra and striatum) and the hippocampus. Our data showed that(More)
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