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In Saccharomyces cerevisiae, the stability of highly repetitive rDNA array is maintained through transcriptional silencing. Recently, a β-1,3-glucanosyltransferase Gas1 has been shown to play a significant role in the regulation of transcriptional silencing in S. cerevisiae. Here, we show that the gas1Δ mutation increases rDNA silencing in a Sir2-dependent(More)
BACKGROUND Telomere erosion can lead to genomic instability and cancer progression. It has been suggested that the shortest telomere, not the average telomere length (TL), is critical for cell viability. Some studies have shown shorter TL in myelodysplastic syndrome (MDS) patients but the critically short telomeres, the variability of TL within individual(More)
There has been recent research into continuous monitoring of the quantitative anesthesia (ANES) depth level for safe surgery [1]. However, the current ANES depth monitoring approach, bispectral index (BIS) [3], uses only EEG from the frontal lobe, and it shows critical limitations in the monitoring of ANES depth such as signal distortion due to(More)
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