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Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation.

Delta-catenin interaction with p190RhoGEF, and the importance of Akt1-mediated phosphorylation at Thr-454 residue of delta-Catenin in this interaction is demonstrated, and signaling events in the regulation of Delta- catenin-induced dendrogenesis and spine morphogenesis are highlighted.
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Protein kinase A phosphorylates and regulates dimerization of 14‐3‐3ζ

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RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation.

It is demonstrated that RANKL induces HAT-mediated NFATc1 acetylation and stability, and subsequently increases the transcriptional activity of NFAT c1 during osteoclast differentiation.
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Increased expression of Nrf2/ARE-dependent anti-oxidant proteins in tamoxifen-resistant breast cancer cells.

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Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation

The results suggest that Akt regulates osteoblast differentiation, at least in part, by enhancing the protein stability and transcriptional activity of Runx2 through regulation of ubiquitin/proteasome‐mediated degradation of Smurf2.
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Lichen Secondary Metabolites in Flavocetraria cucullata Exhibit Anti-Cancer Effects on Human Cancer Cells through the Induction of Apoptosis and Suppression of Tumorigenic Potentials

It is found that among 17 lichens species, F. cucullata exhibited the most potent cytotoxicity in several human cancer cells, and its subcomponent, usnic acid together with additional component, exert anti-cancer effects onhuman cancer cells through the induction of apoptosis and the inhibition of EMT.
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Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells.

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Melatonin promotes osteoblast differentiation by regulating Osterix protein stability and expression

It is suggested that melatonin directly regulates the late stage of osteoblast differentiation by enhancing Osterix expression, providing further evidence of melatonin as a potent agent for treating osteoporosis.
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Osterix is regulated by Erk1/2 during osteoblast differentiation.

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Smurf2 regulates the degradation of YY1.

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