Myung-Shik Lee19
Jae Hyeon Kim16
Yong-Ki Min12
19Myung-Shik Lee
16Jae Hyeon Kim
12Yong-Ki Min
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  • Hyo-Sup Kim, You-Cheol Hwang, Seung-Hoi Koo, Kyong Soo Park, Myung-Shik Lee, Kwang-Won Kim +1 other
  • 2013
BACKGROUND It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells. We investigated whether PPAR-γ activation stimulates insulin secretion through the up-regulation of GPR40 in pancreatic β-cells. METHODS Rat insulinoma INS-1 cells and primary rat islets were(More)
OBJECTIVE Diabetic nephropathy is damage to the kidney caused by diabetes mellitus. It is a common complication and a leading cause of death in people with diabetes. However, the decline in kidney function varies considerably between patients and the determinants of diabetic nephropathy have not been clearly identified. Therefore, it is very difficult to(More)
  • Myoung Sook Han, Kun Wook Chung, Hyae Gyeong Cheon, Sang Dal Rhee, Chang-Hwan Yoon, Moon-Kyu Lee +2 others
  • 2009
OBJECTIVE Imatinib has been reported to induce regression of type 2 diabetes in chronic leukemia patients. However, the mechanism of diabetes amelioration by imatinib is unknown, and it is uncertain whether imatinib has effects on type 2 diabetes itself without other confounding diseases like leukemia. We studied the effect of imatinib on diabetes in db/db(More)
BACKGROUND Concern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and(More)
Although many studies have reported an association between total white blood cell count and metabolic syndrome, relatively few reports are available on the association between differential white blood cell counts and metabolic syndrome. The medical records of 15,654 subjects (age, median 46, range 14-90 yr; 8,380 men and 7,274 women) who visited the Center(More)
  • Wenying Quan, Hyun-Kyong Kim, Eun-Yi Moon, Su Sung Kim, Cheol Soo Choi, Masaaki Komatsu +5 others
  • 2012
Autophagy is a catabolic cellular process involving the degradation of the cell's own components. Although the role of autophagy of diverse tissues in body metabolism has been investigated, the importance of autophagy in hypothalamic proopiomelanocortin (POMC) neurons, key regulators of energy balance, has not been addressed. The role of autophagy in leptin(More)
Diabetes mellitus is a serious and growing health problem worldwide and is associated with severe acute and chronic complications. Moreover, epidemiologic evidence suggests that people with diabetes are at significantly higher risk for many forms of cancer. Several studies indicate an association between diabetes and the risk of liver, pancreas,(More)
Resistance to thyroid hormone (RTH) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features. The magnitude of RTH is caused by mutations in the thyroid hormone receptor beta (TR beta) gene. We recently treated a 38-yr-old woman with RTH who had incidental papillary thyroid carcinoma.(More)
Our study was performed to determine whether cardiac autonomic neuropathy can predict deterioration of the renal function in normoalbuminuric, normotensive people with type 2 diabetes mellitus (DM). One hundred and fifty-six normoalbuminuric, normotensive people with type 2 DM were included in our retrospective longitudinal study. We categorized normal(More)
BACKGROUND/AIMS We investigated the clinical characteristics and follow-up findings of subjects with adrenal incidentalomas in a single, tertiary-care hospital in South Korea. METHODS The study consisted of a retrospective analysis of 282 adrenal incidentaloma patients who underwent radiographic and endocrinological evaluations at Samsung Medical Center(More)