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Euonymus alatus extract attenuates LPS-induced NF-κB activation via IKKβ inhibition in RAW 264.7 cells.
AIM OF THE STUDY The present study was performed to investigate the underlying mechanisms of anti-inflammatory effects with the extract of Euonymus alatus (EEA), and specially focused on nuclear… Expand
Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure.
- Geum Shil Hwang, Kwang-Seok Oh, H. Koo, H. Seo, K. You, B. Lee
- European journal of pharmacology
- 1 July 2006
The present study was performed to evaluate the effects of (2S, 3S, 4R)-N"-cyano-N-(6-amino-3, 4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran-4yl)-N'-benzylguanidine (KR-31378), a… Expand
Vasorelaxant effect of stilbenes from rhizome extract of rhubarb (Rheum undulatum) on the contractility of rat aorta.
- M. Y. Yoo, Kwang-Seok Oh, +6 authors B. Lee
- Medicine, Biology
- Phytotherapy research : PTR
- 1 February 2007
The vascular relaxant effect of the rhizome extract of Rheum undulatum was evaluated with isolated rat thoracic aorta preparations. The methanol extract of the rhizome induced a… Expand
Growth factors mobilize multiple pools of KCa channels in developing parasympathetic neurons: role of ADP-ribosylation factors and related proteins.
In developing ciliary ganglion (CG) neurons, movement of functional large-conductance (BK type) Ca(2+)-activated K+ (K(Ca)) channels to the cell surface is stimulated by the endogenous growth factors… Expand
Expression and purification of an ACE-inhibitory peptide multimer from synthetic DNA in Escherichia coli
An angiotensin I-converting enzyme (EC 126.96.36.199) (ACE), which can convert inactive angiotensin I into angiotensin II, a vasoconstrictor, is one of the key enzymes in controlling hypertension. It is… Expand
IKKβ inhibitor identification: a multi-filter driven novel scaffold
- S. Nagarajan, H. Choo, +4 authors A. N. Pae
- Medicine, Computer Science
- BMC Bioinformatics
- 15 October 2010
BackgroundNuclear factor kappa B (NF-κB) is a chief nuclear transcription factor that controls the transcription of various genes; and its activation is tightly controlled by Inhibitor kappa B kinase… Expand
Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy.
- Hyeseung Song, Yun Suk Lee, +5 authors K. J. Shin
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 1 September 2012
Regulation of NF-κB activation through the inhibition of IKKβ has been identified as a promising target for the treatment of inflammatory and autoimmune disease such as rheumatoid arthritis. In order… Expand
Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ.
- Kwang-Seok Oh, B. Oh, Ji-hye Mun, H. Seo, B. Lee
- Medicine, Chemistry
- International immunopharmacology
- 1 November 2011
Salvianolic acid A, an active compound present in Salvia miltiorrhiza, is a phenolic carboxylic acid derivative, ((2R)-3-(3,4-Dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)… Expand
Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger.
We evaluated the cardioprotective effects of 4-cyano (benzo[b]thiophene-2-carbonyl)guanidine (KR-33028), a recently developed inhibitor of the Na+/H+ exchanger (NHE), on hypoxia-induced H9c2 cell… Expand
IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
- S. Nagarajan, M. Doddareddy, +4 authors A. N. Pae
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 April 2009
Control of NF-kappaB release through the inhibition of IKKbeta has been identified as a potential target for the treatment of inflammatory and autoimmune diseases. We have employed structure based… Expand