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Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment
TLDR
This review highlights the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs and provides better therapeutic rationales to accompany novel anticancer therapeutics.
Interferon‐induced transmembrane protein 1‐mediated EGFR/SOX2 signaling axis is essential for progression of non‐small cell lung cancer
TLDR
It is demonstrated that a high level of IFITM1 expression is associated with a poor overall survival (OS) rate in adenocarcinoma but not in squamous cell carcinoma, and it is suggested that IFITm1 is a poor prognostic marker of adenOCarcinomas and an attractive target to develop novel therapeutics for NSCLC.
Ginsenoside Rd Inhibits the Metastasis of Colorectal Cancer via Epidermal Growth Factor Receptor Signaling Axis
TLDR
It is found that ginsenoside Rd decreased the colony‐forming ability, migration, invasion, and wound‐healing abilities of CRC cells, although it did not affect cell proliferation.
20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis
TLDR
Findings highlighted the potential use of ginsenoside Rg3R in clinical applications for colorectal cancer treatment and potentially mediated by significant down-regulation of the expression of stemness genes and EMT markers in CRC cells in a SNAIL-dependent manner.
AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth
TLDR
It is found that leukemic stem cells were highly differentiated, and leukemia progression was severely impaired in the absence of AMD1 in vivo, indicating that AMD1 is an essential element in the progression of myeloid leukemia and could be an attractive target for the treatment of the disease.
miR551b Regulates Colorectal Cancer Progression by Targeting the ZEB1 Signaling Axis
TLDR
It is indicated that miR551b could serve as a potential diagnostic biomarker and could be utilized to improve the therapeutic outcomes of CRC patients and ZEB1 was associated with the disease progression in CRC patients.
Abstract 5148: Secreted ccdc80 from hepatic stellate cell promote invasion and epithelial-mesenchymal transition in hepatocellular carcinoma
TLDR
Secreted ccdc80 from hepatic stellate cell promote invasion and epithelial-mesenchymal transition in hepatocellular carcinoma and might be a novel biomarker and therapeutic target for patients with HCC.
Circulating Exosomal miR-1290 for Diagnosis of Epithelial Ovarian Cancer
TLDR
Serum exosomal miR-1290 could be considered as a biomarker for differential diagnosis of EOC from benign ovarian neoplasm and SOCS4 might be potential target gene of the miRNA for exploring the molecular mechanisms in EOC.
miR 551 b Regulates Colorectal Cancer Progression by Targeting the ZEB 1 Signaling Axis
TLDR
It is indicated that miR551b could serve as a potential diagnostic biomarker and could be utilized to improve the therapeutic outcomes of CRC patients and ZEB1 was associated with the disease progression in CRC patients.