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The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
Loss of Hippo signaling in Drosophila leads to tissue overgrowth as a result of increased cell proliferation and decreased cell death. YAP (a homolog of Drosophila Yorkie and target of the HippoExpand
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A crucial role of WW45 in developing epithelial tissues in the mouse
The role and molecular mechanisms of a new Hippo signalling pathway are not fully understood in mammals. Here, we generated mice that lack WW45 and revealed a crucial role for WW45 in cell‐cycle exitExpand
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Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer
Pancreatic cancer is characterized by an immunosuppressive tumor microenvironment (TME) with a profound immune infiltrate populated by a significant number of myeloid-derived suppressor cellsExpand
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miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4.
The myogenic capacity of myoblasts decreases in skeletal muscle with age. In addition to environmental factors, intrinsic factors are important for maintaining the regenerative potential of muscleExpand
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Genome-wide profiling of the microRNA-mRNA regulatory network in skeletal muscle with aging
Skeletal muscle degenerates progressively, losing mass (sarcopenia) over time, which leads to reduced physical ability and often results in secondary diseases such as diabetes and obesity. TheExpand
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Prediction of sarcopenia using a combination of multiple serum biomarkers
Sarcopenia is a gradual loss of skeletal muscle mass and function with aging. Given that sarcopenia has been recognized as a disease entity, effective molecular biomarkers for early diagnosis areExpand
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Nucleoredoxin promotes adipogenic differentiation through regulation of Wnt/β-catenin signaling[S]
Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissueExpand
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Bacteria-derived metabolite, methylglyoxal, modulates the longevity of C. elegans through TORC2/SGK-1/DAF-16 signaling
Significance The molecular mechanisms by which gut microbes modulate host longevity remain elusive. Using genome-wide lifespan screens and extensive interspecies genetic analysis, we identified thatExpand
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Peroxiredoxin 3 has a crucial role in the contractile function of skeletal muscle by regulating mitochondrial homeostasis.
Antioxidant systems against reactive oxygen species (ROS) are important factors in regulating homeostasis in various cells, tissues, and organs. Although ROS are known to cause to muscular disorders,Expand
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STAT5A‐mediated NOX5‐L expression promotes the proliferation and metastasis of breast cancer cells
ABSTRACT NADPH oxidase (NOX) generates reactive oxygen species (ROS) and has been suggested to mediate cell proliferation in some cancers. Here, we show that an increase in the expression of NOX5Expand
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