Kwabena Ofori-Kwakye

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BACKGROUND & OBJECTIVES The artemisinin-based antimalarial medicines are first line medicines in the treatment of severe and uncomplicated falciparum malaria. Numerous brands of these medicines manufactured in various countries are available in the Ghanaian market. The study was aimed at evaluating the authenticity and quality of selected brands of(More)
The aim of this study was to formulate and evaluate the physical properties of two tablet formulations of metformin and paracetamol intended for fast disintegration and release in the gastrointestinal tract. The tablet formulations were prepared using similar excipients and manufacturing procedure in a local manufacturing site in Ghana over a ten (10) month(More)
The gastrointestinal transit and in vivo drug release behaviour of a film-coated tablet formulation was investigated in five healthy human subjects using the technique of gamma scintigraphy. The film coating system consisted of a mixture of pectin, chitosan and HPMC in a ratio of 6:1:0.37 applied to 750 mg cores at a coat weight gain of 9%. The estimated(More)
Nanosuspensions of the anti-oxidant resveratrol (5%) were produced for dermal application. Production was performed by high pressure homogenization, applying 1.500 bar up to 30 cycles. Four nanosuspensions were investigated using the stabilizers Tween 80, Poloxamer 188, Plantacare 2000 and Inutec SP1, 1% and 2% respectively. The nanosuspensions were(More)
Fifteen (15) Ghanaian children with uncomplicated malaria were administered oral amodiaquine (AQ) suspension (10 mg/kg body weight) in a single dose study. Urine samples were serially collected over a 30 h period and AQ in the unmetabolized form was determined by ultraviolet spectroscopy. The pharmacokinetic parameters investigated were the fraction of(More)
Mixed films containing pectin, chitosan and HPMC, prepared by solvent casting from 0.1 M HCl (pH 1.5) and 0.1 M acetic acid (pH 2.9) were evaluated for their morphological and leaching properties. Films cast at pH 1.5 were uniform with smooth surfaces while films cast at pH 2.9 showed particle aggregation and had rough surfaces due to polyelectrolyte(More)
A study was carried out into the biphasic drug release properties of film-coated paracetamol tablets. The tablet cores were formulated without a disintegrant and film-coated with a coating formulation consisting of pectin, chitosan and hydroxypropylmethylcellulose in a ratio of 6:1:0.37. The tablet cores and the film-coated tablets with coat weight gains(More)
The permeabilities of mixed films of pectin/chitosan/HPMC have been studied to assess their value in producing a dosage form with biphasic drug release characteristics. The inclusion of chitosan enhanced the properties of the films, rendering them stable at all physiological pH values. Pectin/HPMC films were soluble at pH values above 3.0. All(More)
The antibacterial activity of the aqueous, ethanol, methanol and petroleum ether Soxhlet extracts of sundried stem bark of Spathodea campanulata P. Beauv. (Bignoniaceae) was investigated by testing the extracts against B. subtilis, E. coli, P. aeruginosa and S. aureus. The minimum inhibitory concentration (MIC) of the methanol extract was determined against(More)