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- Kusum K Kharbanda, Mark E. Mailliard, Cheryl R Baldwin, Harriet C Beckenhauer, Michael F. Sorrell, Dean J. Tuma
- Journal of hepatology
- 2007
BACKGROUND/AIMS
Previous studies in our laboratory implicated ethanol-induced decreases in hepatocellular S-adenosylmethionine to S-adenosylhomocysteine (SAM:SAH) ratios in lowering the activity of… (More)
- Kusum K Kharbanda, David Rogers, +5 authors Dean J. Tuma
- Biochemical pharmacology
- 2005
Previous studies from our laboratory have shown that ethanol consumption results in an increase in hepatocellular S-adenosylhomocysteine levels. Because S-adenosylhomocysteine is a potent inhibitor… (More)
- Vishnudutt Purohit, Manal F. Abdelmalek, +9 authors Samir Zakhari
- The American journal of clinical nutrition
- 2007
This report is a summary of a symposium on the role of S-adenosylmethionine (SAM), betaine, and folate in the treatment of alcoholic liver disease (ALD), which was organized by the National Institute… (More)
- Kusum K Kharbanda
- Seminars in liver disease
- 2009
Alcoholic liver disease is a major health care problem worldwide. Findings have demonstrated that ethanol feeding impairs several of the multiple steps in methionine metabolism that leads to… (More)
- Shannon M. Bailey, Gloria Robinson, +10 authors Victor M. Darley-Usmar
- American journal of physiology. Gastrointestinal…
- 2006
An early event that occurs in response to alcohol consumption is mitochondrial dysfunction, which is evident in changes to the mitochondrial proteome, respiration defects, and mitochondrial DNA… (More)
- Murali Ganesan, Jin-jin Zhang, +5 authors Natalia A Osna
- American journal of physiology. Gastrointestinal…
- 2015
Alcohol exposure worsens the course and outcomes of hepatitis C virus (HCV) infection. Activation of protective antiviral genes is induced by IFN-α signaling, which is altered in liver cells by… (More)
- Anthony J. Barak, Harriet C Beckenhauer, Mark E. Mailliard, Kusum K Kharbanda, Dean J. Tuma
- The Journal of nutrition
- 2003
Previous studies showed that chronic ethanol administration inhibits methionine synthase activity, resulting in impaired homocysteine remethylation to form methionine. This defect in homocysteine… (More)
- Michael L. McCaskill, Kusum K Kharbanda, +4 authors Todd A Wyatt
- Alcoholism, clinical and experimental research
- 2011
BACKGROUND
Most alcohol abusers smoke cigarettes and approximately half of all cigarette smokers consume alcohol. However, no animal models of cigarette and alcohol co-exposure exist to examine… (More)
- Todd A Wyatt, Kusum K Kharbanda, +4 authors Joseph H. Sisson
- Alcohol
- 2012
In addition to cigarette smoking, alcohol exposure is also associated with increased lung infections and decreased mucociliary clearance. However, little research has been conducted on the… (More)
- Kusum K Kharbanda
- Current opinion in clinical nutrition and…
- 2013
PURPOSE OF REVIEW
To outline recent advances in the understanding of the consequences of the alterations in the methionine metabolic pathway and to present new treatment options for alcoholic liver… (More)