Kurt Thomas Barnhart

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OBJECTIVE To investigate the IVF outcome for patients with endometriosis. DESIGN Meta-analysis. SETTING Academic research center. PATIENT(S) A MEDLINE search and review of the literature were performed. Patients were classified by level of endometriosis, and controls were classified according to the indication for IVF. INTERVENTION(S) Bivariate(More)
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in(More)
OBJECTIVE To evaluate the predictive value of sperm DNA integrity tests for pregnancy from in vitro fertilization treatment. DESIGN Systematic review and meta-analysis. SETTING Studies from infertility centers. PATIENT(S) Infertile couples undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. INTERVENTION(S)(More)
BACKGROUND Recurrent pregnancy loss (RPL) is a significant clinical problem. Recently, thrombophilias have been implicated as a possible cause. Factor V Leiden (FVL) and prothrombin gene (G20210A) mutations are the most common types of hereditary thrombophilias, but are usually undiagnosed because most carriers are asymptomatic. The relationship between(More)
OBJECTIVE Medical management of an unruptured ectopic pregnancy with intramuscular methotrexate is common and cost-effective. Two treatment protocols, the "single dose" and the "multidose," have been advocated and independently reported in the medical literature. This analysis systematically compares the success and prevalence of side effects of these two(More)
CONTEXT A large body of evidence documents the role of phytoestrogens in influencing hormone-dependent states. Infants fed soy formula receive high levels of phytoestrogens, in the form of soy isoflavones, during a stage of development at which permanent effects are theoretically possible. However, a paucity of data exists on the long-term effects of infant(More)
OBJECTIVE To estimate whether extended embryo culture is associated with preterm delivery, very preterm delivery, low birth weight, or a combination of these in neonates conceived through in vitro fertilization (IVF). METHODS U.S. IVF live births were identified using the Society of Assisted Reproductive Technologies database (2004-2006). Associations(More)
OBJECTIVE To improve the interpretation of future studies in women who are initially diagnosed with a pregnancy of unknown location (PUL), we propose a consensus statement with definitions of population, target disease, and final outcome. DESIGN A review of literature and a series of collaborative international meetings were used to develop a consensus(More)
Copyright © 2009 Massachusetts Medical Society. A healthy 29-year-old woman who has been trying to conceive presents with vaginal spotting for the past 5 days and intermittent crampy abdominal pain in her left lower quadrant for the past 3 days. Although she normally has regular menstrual cycles, her last menstrual period was 6 weeks and 2 days before(More)
OBJECTIVE Successful medical management of an ectopic pregnancy is inversely associated with initial hCG level. The purpose of this publication is to assess whether there is a level of hCG above which failure rate substantially increases. DESIGN A systematic review and summary analysis was performed, including studies reporting methotrexate treatment(More)