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  • Ben A. Croker, Joanne A O'Donnell, +15 authors Andrew W. Roberts
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2011 (First Published: 9 August 2011)
  • During immune responses, neutrophils must integrate survival and death signals from multiple sources to regulate their lifespan. Signals that activate either the Bcl-2- or death receptor-regulatedContinue Reading
  • George Au-Yeung, Franziska Lang, +12 authors David D. L. Bowtell
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2017 (First Published: 1 April 2017)
  • Purpose: Cyclin E1 (CCNE1) amplification is associated with primary treatment resistance and poor outcome in high-grade serous ovarian cancer (HGSC). Here, we explore approaches to targetContinue Reading
  • Kurt Lackovic, John P Parisot, +7 authors Lukasz Kedzierski
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 2010 (First Published: 1 May 2010)
  • The current treatment for leishmaniasis is based on chemotherapy, which relies on a handful of drugs with serious limitations, such as high cost, toxicity, and a lack of efficacy in regions ofContinue Reading
  • Brad E Sleebs, Michelle Gazdik, +7 authors Justin A Boddey
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2014 (First Published: 25 September 2014)
  • Following erythrocyte invasion, malaria parasites export a catalogue of remodeling proteins into the infected cell that enable parasite development in the human host. Export is dependent on theContinue Reading
  • Ankita Gupte, Emma K. Baker, +17 authors Carl R Walkley
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2015 (First Published: 15 July 2015)
  • PURPOSE Osteosarcoma is the most common cancer of bone occurring mostly in teenagers. Despite rapid advances in our knowledge of the genetics and cell biology of osteosarcoma, significantContinue Reading
  • Auda A. Eltahla, Kurt Lackovic, Christopher Marquis, John-Sebastian Eden, Peter A White
  • Biology, Medicine
  • Journal of biomolecular screening
  • 2013 (First Published: 1 October 2013)
  • The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) plays an essential role in the replication of HCV and is a key target for novel antiviral therapies. Several RdRp inhibitors are inContinue Reading
  • Kurt Lackovic, Guillaume Lessene, Hendrik Falk, Karl-Johan Leuchowius, Jonathan Baell, Ian Phillip Street
  • Chemistry, Medicine
  • Combinatorial chemistry & high throughput…
  • 2014 (First Published: 31 March 2014)
  • The Walter and Eliza Hall Institute of Medical Research (WEHI) is Australia's longest serving medical research institute. WEHI's High Throughput Screening (HTS) Facility was established in 2003 withContinue Reading