Kurt Kochsiek

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BACKGROUND In patients with heart failure due to dilated cardiomyopathy, cardiac energy metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to-ATP ratio, measured noninvasively by 31P-MR spectroscopy. The purpose of this study was to test whether the phosphocreatine-to-ATP ratio also offers prognostic information in terms(More)
Integrins and other adhesion receptors are essential components for outside-in and inside-out signaling through the cell membrane. The platelet glycoprotein IIb-IIIa (also known as fibrinogen receptor or integrin alpha IIb beta 3) is activated by platelet agonists, inhibited by cyclic-nucleotide-elevating agents, and is involved in the activation of protein(More)
In a study of 20 patients with hypercholesterolemia (type IIa) the effects of lovastatin (20–80 mg/ day) on various clotting and thrombosis parameters were monitored for 12 months. On 11 occasions various cholesterol fractions and clotting parameters were determined in each patient. In additon, the clotting inhibitors AT III, protein C, protein S, and(More)
Survival after myocardial infarction decreases with left ventricular dilatation, although dilatation at 4 weeks was found to be compensatory. To study this apparent discrepancy, prospective simultaneous volume and hemodynamic measurements at rest were extended in 39 patients with small and 37 with large myocardial infarctions from 4 (range 2 to 6) days and(More)
Bei 35 Patienten mit Vorhofseptumdefekt wurden die Beziehungen zwischen hämodynamischen und elektrokardiographischen Größen untersucht. Ein Einfluß des Shuntvolumens auf den Beginn der größten Negativitätsbewegung im Bereich des rechten Ventrikels konnte nicht nachgewiesen werden. Dagegen fand sich eine deutliche-wenn auch im Einzelfall nicht(More)
Bei 42 Patienten mit Ventrikelseptumdefekt wurden die Beziehungen zwischen hämodynamischen und elektrokardiographischen Größen untersucht. Es erwies sich in der Mehrzahl der Fälle als möglich, Ventrikelseptumdefekte mit rechtsventrikulärer Drucksteigerung durch das Ekg zu erfassen. Eine mäßige positive Korrelation bestand zwischen den rechtsventrikulären(More)
Analyse einen Hinweis auf den Grad einer Zellseh/~digung, ob eytoplasmatisch oder mitoehondriat, ein. Weitere Untersuchungen fiber diese Probleme sind im Gange und werden an anderer Stelle publiziert. Literatur. ~ ]=IINsBEI~G, I~. : Scand. J . elin. Lab. Invest. 1O, Suppl. 31 ( 1 9 5 7 ) . e Bnow~, g . K. : Klin. Wsehr. 1958, 1. ~ H~ss, B., u. E. G E ~ :(More)
A twenty-five years old man was found to have simultaneous total deficiency of thyroxine-binding globulin (“thyropexin”) and hereditary hypertrophic obstructive cardiomyopathy (HOCM). The thyroxine-binding capacity (RT3U), thyroid hormone levels, PB127I, PB131I and TBG (RIA) in serum were very low and TBG cap was zero. Trapping of radioiodine in the thyroid(More)
A radioimmunoassay for digoxin in human serum is described. Sufficiently high antibody concentrations were obtained after immunization of rabbits for 8 months against digoxin bound to human albumin. Standard curves in the presence of antidigoxin antibody concentrations binding 40–70% radioactive digoxin allow determinations of digoxin in human serum from(More)