Kurt Kochsiek

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BACKGROUND In patients with heart failure due to dilated cardiomyopathy, cardiac energy metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to-ATP ratio, measured noninvasively by 31P-MR spectroscopy. The purpose of this study was to test whether the phosphocreatine-to-ATP ratio also offers prognostic information in terms(More)
A radioimmunoassay for digoxin in human serum is described. Sufficiently high antibody concentrations were obtained after immunization of rabbits for 8 months against digoxin bound to human albumin. Standard curves in the presence of antidigoxin antibody concentrations binding 40–70% radioactive digoxin allow determinations of digoxin in human serum from(More)
BACKGROUND Coxsackievirus B3 and B4 (CVB) myocarditis was assessed by a more than twofold change in titer of the microneutralization tests against enteroviruses within 3 weeks in all patients, by an endomyocardial biopsy indicative of active myocarditis in eight cases, and by pericardial effusion and acute cardiomegaly in two patients. In all endomyocardial(More)
In an animal preparation of congestive heart failure in the dog, during the development of cardiac failure due to rapid right ventricular pacing we observed significant decreases in cardiac output and arterial pressure and increases in pulmonary arterial and right atrial pressure. We also observed a related increase in right atrial pressure and increases in(More)
Circulating muscle-specific antimyolemmal antibodies (AMLAs) were found in 18 of 61 patients with secondary dilated cardiomyopathy (DC). All 18 patients had clinical or histologic evidence of previous perimyocarditis. AMLAs were found both in patients' serum samples and bound to the sarcolemmal sheath of the autologous myocardial biopsy specimen. Only AMLAs(More)
Using submitochondrial particles (SMP) from beef heart, pig kidney and rat liver in the ELISA, we detected partial organ specific anti-mitochondrial antibodies (AMA) against heart and kidney SMP in sera from patients with different forms of cardiomyopathies. Serum samples from 50 of 159 patients with congestive or hypertrophic cardiomyopathy (31%) and from(More)
In advanced heart failure, severe edema develops associated with hyponatremia. In 20 patients with severe congestive heart failure, we studied plasma antidiuretic hormone (ADH) concentrations related to hemodynamics and plasma osmolality. Prazosin was used to test the acute response to changes in atrial receptors and hemofiltration to test the response to(More)
Lactate measurements can be performed within 2-3 minutes after blood withdrawal from the patients by using an electrochemical enzymatic sensor for lactate. The values obtained reflect the actual state of the patient which is not the case with the slow classical method using lactate dehydrogenase and NAD. The sensor is reproducible and the influence of the(More)
Sera of 177 patients with acute myocarditis (10 coxsackie B 3/4, four influenza, four mumps, 15 cytomegalovirus, 144 undefined) were tested by indirect immunofluorescence for autoantibodies against heart and skeletal muscle and vital or air-dried adult cardiocytes. Antibody-dependent cytolysis, lymphocytotoxicity and antibody-dependent cellular(More)
Alpha atrial natriuretic peptide was measured in plasma in 7 patients with severe heart failure before and after the administration of the synthesized substance. An inverse correlation was found between basal plasma levels of alpha atrial natriuretic peptide and cardiac output. Incremental bolus injections of synthetic alpha atrial natriuretic peptide and(More)