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A syndrome of motoric and neuropsychiatric symptoms comprising various elements, including chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur in association with group A beta-hemolytic streptococcal (GABHS) infection. We tested the hypothesis that an immune response to GABHS can result in behavioral abnormalities.(More)
Differential, structural, and absolute stability of babyfaceness and attractiveness at 5 ages were investigated. Attractiveness had differential stability across the life span. Babyfaceness had differential stability from childhood through the 30s for males and through adolescence for females. Consistent with sexual dimorphisms in facial maturation, males(More)
INTRODUCTION The extensive comorbidity among psychiatric disorders underscores the need for a fundamental change in the way psychopathology is classified. An alternative 'dimensional' system classifies disorders based on relationships with respect to heritability patterns and comorbidity. It is from this 'dimensional view' that mouse modeling of(More)
Neuronal death occurs during normal development and disease and can be regulated by steroid hormones. In the hawkmoth, Manduca sexta, individual accessory planta retractor (APR) motoneurons undergo a segment-specific pattern of programmed cell death (PCD) at pupation that is triggered directly and cell autonomously by the steroid hormone 20-hydroxyecdysone(More)
In the rat, social isolation during the early postnatal period disrupts the adult function of certain neuroendocrine and neurobehavioral systems. In the present study, we assessed the effects of peer and maternal contact during this period on the adult expression of aggression, maternal behavior, and the behavioral response to novelty. Female rat pups of(More)
INTRODUCTION Obsessive compulsive disorder (OCD) is a debilitating condition with limited treatment options. OCD is heterogeneous with respect to the content of obsessions and compulsions and their underlying motivation, among other characteristics. Animal models have provided important insights into the pathophysiology of OCD. AREAS COVERED The(More)
1. THE JORDAN SORTING PROBLRMS. Let C be a Jordan curve in the plane and let x,,x2,,..,xn be the abscissas of the intersection points of C with the x-axis, listed in the order the points occur on C. (See Figure 1). We call a sequence of real numbers x x ,' 2*...Jn obtainable in this way a Jordan sequence. In this paper we consider the problem of recognizing(More)
The tip of each proleg in Manduca sexta larvae bears a dense array of mechanosensory hairs termed planta hairs (PHs), each innervated by a single sensory neuron (termed a PH-SN) located in the underlying epidermis. In the CNS, axon terminals of PH-SNs make direct, excitatory, nicotinic cholinergic synapses with proleg retractor motoneurons including the(More)
Nest building behavior in the pregnant female rabbit (Oryctolagus cuniculus) is a model for compulsive behavior in Obsessive Compulsive Disorder (OCD). This behavior comprises a cycle of repeated, stereotyped components (collecting straw, entering nest box and depositing the straw there, returning to collect more straw), which itself is repeated 80+ times(More)