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A syndrome of motoric and neuropsychiatric symptoms comprising various elements, including chorea, hyperactivity, tics, emotional lability, and obsessive-compulsive symptoms, can occur in association with group A beta-hemolytic streptococcal (GABHS) infection. We tested the hypothesis that an immune response to GABHS can result in behavioral abnormalities.(More)
Studies in humans indicate that acute administration of sub-anesthetic doses of ketamine, an NMDA receptor antagonist, provokes schizophrenic-like symptoms in healthy volunteers, and exacerbates existing symptoms in individuals with schizophrenia. These and other findings suggest that NMDA receptor hypofunction might participate in the pathophysiology of(More)
Neuronal death occurs during normal development and disease and can be regulated by steroid hormones. In the hawkmoth, Manduca sexta, individual accessory planta retractor (APR) motoneurons undergo a segment-specific pattern of programmed cell death (PCD) at pupation that is triggered directly and cell autonomously by the steroid hormone 20-hydroxyecdysone(More)
In the rat, social isolation during the early postnatal period disrupts the adult function of certain neuroendocrine and neurobehavioral systems. In the present study, we assessed the effects of peer and maternal contact during this period on the adult expression of aggression, maternal behavior, and the behavioral response to novelty. Female rat pups of(More)
Little is known of the neural mechanisms underlying the subjective experience of task completion and the subsequent inhibition of behavior. The preparturient female rabbit displays a stereotyped "straw carrying" behavior, in which she repeatedly collects straw and carries it into a nest box (located within the home cage), resulting in a finished maternal(More)
Nest building behavior in the pregnant female rabbit (Oryctolagus cuniculus) is a model for compulsive behavior in Obsessive Compulsive Disorder (OCD). This behavior comprises a cycle of repeated, stereotyped components (collecting straw, entering nest box and depositing the straw there, returning to collect more straw), which itself is repeated 80+ times(More)
INTRODUCTION The extensive comorbidity among psychiatric disorders underscores the need for a fundamental change in the way psychopathology is classified. An alternative 'dimensional' system classifies disorders based on relationships with respect to heritability patterns and comorbidity. It is from this 'dimensional view' that mouse modeling of(More)
The rat prostate comprises dorsal, ventral and lateral lobes that are morphologically and biochemically distinct. Lesions to these structures are expected to affect the quality of the ejaculate and male fertility. In experiment 1, we analyzed ejaculate parameters of males that had chemical lesions of the dorsal or ventral lobes. At pre-lesion and at 5 and(More)