Kurt A. McCammon

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The hemagglutinin of influenza virus is synthesized as a monomeric subunit that is cotranslationally translocated across the membrane of the rough endoplasmic reticulum. We show that folding and assembly of hemagglutinin monomers into trimeric structures takes approximately 7-10 min and is completed before the protein leaves the endoplasmic reticulum.(More)
OBJECTIVES To present the urodynamic changes and early results associated with the AdVance male sling. The AdVance male sling is a treatment option for postprostatectomy incontinence (PPI), with the goal of eliminating urinary incontinence without affecting voiding parameters. A concern of any procedure in treating men with PPI is whether the treatment(More)
PURPOSE We report our experience and long-term followup of patients undergoing excision and primary anastomotic reconstruction for anterior urethral strictures. MATERIALS AND METHODS From July 1986 to May 2006 the charts of 260 patients who underwent excision with primary anastomosis at our center for bulbar urethral stricture were reviewed. Patient age(More)
PURPOSE VICTOR was a 12-week, double-blind, placebo controlled trial assessing the safety and tolerability of solifenacin plus tamsulosin in men with residual overactive bladder symptoms after tamsulosin monotherapy. Efficacy of solifenacin plus tamsulosin vs placebo plus tamsulosin was also evaluated. MATERIALS AND METHODS A total of 398 men 45 years old(More)
Two-year outcomes of treating cystocele with a polypropylene mesh (Perigee System® with IntePro®, AMS, Inc.) placed via a transobturator approach are reported. A prospective, multicenter trial was conducted evaluating 114 women with ≥ stage II anterior wall prolapse defined using International Continence Society guidelines. Treatment success was defined as(More)
OBJECTIVES To determine and compare quality-of-life (QOL) evaluations from patients who received external beam radiation therapy or radical prostatectomy for the treatment of localized prostate cancer, and to compare differences in QOL assessments for urinary and sexual function after radical prostatectomy as reported by patient and physician. METHODS Two(More)
OBJECTIVE To review extended patient outcomes after male transobturator sling placement for stress urinary incontinence. METHODS A retrospective review of a prospectively maintained database for patients with at least 12 months of postoperative follow-up after AdVance male sling placement was performed. Success was defined as a dry safety pad or less(More)
Previous studies indicate that bladder instability in man may be associated with increased spontaneous rhythmic contractile activity. Ca2+ influx plays a central role in smooth muscle contractions, and recent evidence suggests that steroid hormones rapidly affect Ca2+ influx. Therefore we tested the hypothesis that estrogen and progesterone modulates(More)
We reviewed the current literature on lichen sclerosus as it related to urethral stricture disease using MEDLINE and PubMed (U.S. National Library of Medicine, National Institutes of Health) up to the current time. We identified 65 reports, 40 of which were considered relevant and form the basis of this review. Lichen sclerosus is now the accepted term, and(More)