Kunio Nakahara

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Kinins, members of a family of peptides released from kininogens by the action of kallikreins, exhibit a variety of biological activities including vasodilation, increased vascular permeability, contraction of smooth muscle cells, and activation of sensory neurons. However, investigation of the physiological actions of kinins has been greatly hampered(More)
ported in the preceding papers1,2). This report describes the structure elucidation of this immunostimulant. FK-156 (1) is a water-soluble acidic peptide, mp 143•` 148°C (dec.), [ƒ¿]25D -30.0° (c 0.5, H2O). 1 has the molecular formula C20H33N5O11„ as confirmed bymicroanalysis and its FD mass spectrum, these pKa' values 4.3, 5.8, 6.3, and 10.9 (67% DMSO)(More)
Airway hyperresponsiveness is a key feature of asthma, and attenuating airway hyperresponsiveness is an important part of asthma therapy. In the present study we examined the inhibitory effect of a potent 5-lipoxygenase inhibitor, FR 110302, on airway hyperresponsiveness induced by ozone exposure in guinea pigs and dogs. Respiratory resistance (R rs) was(More)
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