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Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
TLDR
Results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis, and directly regulates several hundred target messenger RNA molecules.
A vertebrate RNA‐binding protein Fox‐1 regulates tissue‐specific splicing via the pentanucleotide GCAUG
TLDR
It is concluded that Fox‐1 plays key roles in both positive and negative regulation of tissue‐specific splicing via GCAUG, which regulates alternative splicing in vertebrates.
Visualization of primordial germ cells in vivo using GFP-nos1 3'UTR mRNA.
TLDR
It is indicated that the 3'UTR of the zebrafish nos1 mRNA can promote maintenance of RNAs in the PGCs of different fish species, and the migration routes of P GCs in seven teleost species are described and compared.
Zebrafish DAZ‐like protein controls translation via the sequence ‘GUUC’
TLDR
This work has shown that DAZ homologous genes encode RNA‐binding proteins containing two conserved motifs, namely the RNA‐recognition motif (RRM) and the DAZ motif, which are important for gametogenesis in many species.
DAZL Relieves miRNA-Mediated Repression of Germline mRNAs by Controlling Poly(A) Tail Length in Zebrafish
TLDR
The present study indicated that DAZL acts as an “anti-miRNA factor” during vertebrate germ cell development and suggested that miRNA-mediated regulation can be modulated on specific target mRNAs through the poly(A) tail control.
[MicroRNA function in animal development].
  • Kunio Inoue
  • Biology
    Tanpakushitsu kakusan koso. Protein, nucleic acid…
  • 1 March 2007
Inhibition of the First Step in Synthesis of the Mycobacterial Cell Wall Core, Catalyzed by the GlcNAc-1-phosphate Transferase WecA, by the Novel Caprazamycin Derivative CPZEN-45*
TLDR
CPZEN-45 inhibits a novel target in cell wall assembly and was effective against WecA, the ortholog of TagO and involved in the biosynthesis of the mycolylarabinogalactan of the cell wall of M. tuberculosis.
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