Kuniko Kitanishi

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Purpose. To investigate the changes in retinal blood flow (RBF) during a 75-g oral glucose tolerance test in the contralateral eye of patients with retinal branch vein occlusion (BRVO). Methods. Seventeen patients with BRVO were included. None had a known history of diabetes mellitus. The blood velocity and vessel diameter of the upper temporal retinal(More)
Cilostazol is one of a number of anti-platelet agents used for the treatment of thrombotic disorders, such as chronic arterial obstruction, and is a vasodilator as well. In the present study, cilostazol was intravenously administered to seven anesthetized cats, and the optic nerve head (ONH) and choroidal blood flows were continuously monitored in a(More)
The aim of this work was to evaluate the reliability of scanning laser Doppler flowmetry (SLDF) developed by Michelson (Heidelberg retina flowmeter) as compared to fundus camera based laser Doppler flowmetry (FLDF). Blood flow was measured on several occasions by SLDF in the optic nerve head (ONH) and in retinal capillaries of the intervascular area (IV A)(More)
We investigated the change of optic nerve head blood flow (ONHBF) and choroidal blood flow (CBF) in response to noradrenaline (NA) intravenously administered in anesthetized cats. NA (0.03, 0.1, 0.3 micrograms/kg/min) was injected 5 minutes continuously via the femoral vein. The relative blood flow and systemic blood pressure were continuously measured(More)
Forty hospitalized depressive patients of both sexes with primary depressive syndrome and concomitant diurnal variations were investigated at defined times with the following method: special questionnaire on subjective evaluation of depressive diurnal variation (TSF), mood scale (Bf-S of v. Zerssen), Necker cube, tests of autonomic function (amount of(More)
We investigated the effects of intravenous administration of prostaglandin E1 (PGE1) and lipo-prostaglandin E1 (lipo-PGE1), on optic nerve head blood flow (ONHBF) using ten anesthetized cats. Changes in relative ONHBF were noninvasively and continuously measured with fundus camera-based laser Doppler flowmetry. The blood pressure (BP) decreased(More)
Dye-filling rate of optic disc and choroid in normal human subjects was investigated using indocyanine green infra-red videoangiography and computerized image analysis. Only relative changes in the circulation of disc and choroid could be studied and the ratio (D/M) of dye-filling rate in normal subjects (age ranged 23-62) in disc (D) to choroid (M) was(More)
PURPOSE To study the effects of topically applied nipradilol, an alpha-beta blocker recently developed in Japan as an ocular hypotensive drug, on retinal blood flow (RBF) in healthy volunteers. METHODS Seven healthy volunteers (mean age, 33 years) underwent measurement of RBF using a newly developed stabilized laser Doppler velocimetry system. In a(More)
The role of nitric oxide (NO) was evaluated in mediating control of retinal blood flow in the anesthetized cat. This was done under resting conditions and as a function of decreases in perfusion pressure. The retinal blood flow was calculated by measuring blood velocity with laser Doppler velocimetry (LDV) and retinal blood vessel diameter with image(More)
A 45-year-old Japanese women whose left eye contained an elevated, whitish yellow, and multi-lobed mass of 1.5 disc diameters that extended out from the retina adjacent to the optic disc. Ultrasonography demonstrated high reflectivity corresponding to the lesion of the left eye. By fluorecein angiography the tumor showed autofluorescein, retinal vessel(More)