Kunihiko Iizuka

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This article compares the performance of Fuzzy ARTMAP with that of Learned Vector Quantization and Back Propagation on a handwritten character recognition task. Training with Fuzzy ARTMAP to a fixed criterion used many fewer epochs. Voting with Fuzzy ARTMAP yielded the highest recognition rates.
A capacitively coupled probing circuit with a novel de-skewer, a low-pass filter and a high-sensitivity receiver is proposed to realize a membrane-based wafer-level simultaneous testing robustly. The de-skewer can be designed by only digital core transistors and has stable feed-forward architecture. The receiver with the low-pass filter can suppress the(More)
A new topology for a switched-capacitor variable gain amplifier (SC-VGA) is proposed and implemented in an analog-digital interface system for CCD image sensor. The SC-VGA exploits a positive feedback which leads to simpler circuit implementation, lower power consumption and reduced kT/C noise, compared to the conventional one. The gain, controlled by 8-bit(More)
We examined whether changes in intracellular reduced (GSH) or oxidized (GSSG) glutathione of human monocytes regulate lipopolysaccharide (LPS)-induced IL-12 production and defined the molecular mechanism that underlies glutathione redox regulation. Monocytes exposed to glutathione reduced form ethyl ester (GSH-OEt) or maleic acid diethyl ester (DEM)(More)
OBJECTIVE To evaluate osteoporosis in asthmatic patients. METHODS Bone mineral density (BMD) was measured using three different methods, namely computed X-ray densitometry (CXD), digital image processing (DIP), and dual energy X-ray absorptiometry (DXA). The BMD data were standardized using the sex- and age-matched mean value of BMD. PATIENTS One(More)
A 56-year-old woman with diabetic triopathy, rheumatoid arthritis and chronic renal failure was admitted for severe hypoglycemic coma. Arthralgia had been deteriorating for 6 months. Therefore, 5 mg of prednisolone was administered. Postprandial blood glucose (PPG), however, elevated from 260 to 290 mg/dl, although fasting blood glucose (FBG) levels ranged(More)
Recent in vitro studies have shown that the Rho/Rho kinase pathway is involved in the mechanism of not only airway smooth muscle contraction but also vascular endothelial permeability caused by certain stimuli. This suggests that Rho/Rho kinase inhibitors may become useful agents against asthma via reduction of increased airway microvascular leakage, one of(More)
Previously we have reported that Y-27632, a selective inhibitor of Rho-associated protein kinases (ROCKs) for RhoA, suppressed concanavalin A (Con A)-induced secretion of cytokines from peripheral T cells of normal persons. Recent studies suggested its usefulness for clinical management of bronchial asthma. We examined effect of Y-27632 on release of(More)
Y-27632 selectively inhibits Rho-associated protein kinases (ROCKs), an effector for RhoA. The RhoA system is involved in T cell activation. Y-27632 mimicked effects of beta agonists on human cells. We examined the effects of both Y-27632 and Isoproterenol (Iso) on the release of T helper type 1 (Th-1) cytokines (interleukin (IL)-2 and interferon(More)