Kunihiko Goto

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The ClC chloride channels control the ionic composition of the cytoplasm and the volume of cells, and regulate electrical excitability. Recently, it has been proposed that prokaryotic ClC channels are H+-Cl- exchange transporter. Although X-ray and molecular dynamics (MD) studies of bacterial ClC channels have investigated the filter open-close and ion(More)
A hypothesis concerning the molecular changes in the nerve cell membrane during excitation is presented. Based upon established principles about the interaction of hydrophobic and hydrophilic ligands and upon recent facts concerning the contraction of neurofilaments, the hypothesis accounts for both the initiation of the action potential and its conduction(More)
Enclosed please find the original Word files of a new paper entitled " The atomic-level mechanism underlying the functionality of aquaporin-0 ". So far, more than 82,000 protein structures have been reported in the Protein Data Bank, but the driving force and structures that allow for protein functions have not been elucidated at the atomic level for even(More)
By using a piezoelectric sensor, it was demonstrated that the visual evoked potential of a rat brain was accompanied by mechanical movements of the brain when it was excited. A phase of upward movement was found to be followed by a phase of downward movement. The largest upward movement was a rise in swelling pressure on the order of 100 µg, which was about(More)
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