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PURPOSE To clarify the clinical characteristics of exudative age-related macular degeneration (AMD) in Japanese patients. DESIGN Retrospective, observational, consecutive case series. METHODS Two hundred and eighty-nine patients with neovascular AMD were examined. RESULTS The authors classified the patients into three subtypes of neovascular AMD:(More)
PURPOSE To investigate whether photodynamic therapy (PDT) outcomes of polypoidal choroidal vasculopathy (PCV) are related to baseline clinical characteristics, smoking history, or genetic factors by analyzing the retreatment-free period after the first PDT. DESIGN Retrospective cohort study. PARTICIPANTS The study consisted of 167 patients with PCV who(More)
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expressed in choroidal neovascular endothelial(More)
PURPOSE To determine the characteristics of the polymorphisms in the ARMS2 gene in Japanese patients with age-related macular degeneration (AMD) and those with polypoidal choroidal vasculopathy (PCV) and in healthy controls, and also to show possible associations of the polymorphisms with the disease. DESIGN Case-control association study. METHODS(More)
PURPOSE The collagen type I alpha 1 (COL1A1) gene was recently reported to be associated with high myopia in the Japanese population. To validate this positive association, the tag single-nucleotide polymorphism (tSNP) approach was used. METHODS Eight tSNPs, including rs2075555 and rs2269336 (previously reported to be high myopia-susceptible SNPs in the(More)
PURPOSE To investigate the findings of infrared fundus autofluorescence in eyes with central serous chorioretinopathy (CSC). METHODS This study was an observational follow-up of 83 eyes of 80 consecutive patients with CSC recruited from a hospital referral practice. Infrared autofluorescence (IR-AF) findings and those of other clinical studies, including(More)
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