Kung-I Feng

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Publications11
Citations130
Highly Influential Citations10
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Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
  • Bernard R. Neustadt, Jinsong Hao, +12 authors Kung-I Feng
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 March 2007
    • Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson's disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 as… Continue Reading
    Discovery of Ruzasvir (MK-8408): A Potent, Pan-Genotype HCV NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Polymorphisms.
  • Ling Tong, Wensheng Yu, +29 authors Joseph A. Kozlowski
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 12 January 2017
    • We describe the research that led to the discovery of compound 40 (ruzasvir, MK-8408), a pan-genotypic HCV nonstructural protein 5A (NS5A) inhibitor with a "flat" GT1 mutant profile. This NS5A… Continue Reading
    Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments
  • Cecilie Maria Madsen, Kung-I Feng, +4 authors Thomas Rades
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 1 January 2018
    • ABSTRACT The composition of the human intestinal fluids varies both intra‐ and inter‐individually. This will influence the solubility of orally administered drug compounds, and hence, the absorption… Continue Reading
    Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
  • Michel R. Corboz, Maria A. Rivelli, +18 authors John A. Hey
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 April 2011
    • We define the pharmacological and pharmacokinetic profiles of a novel α(2C)-adrenoceptor agonist, compound A [N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-benzoxazin-6-yl]-N-ethyl-N'-methylurea].… Continue Reading
    Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
  • Wensheng Yu, Ling Tong, +22 authors Joseph A. Kozlowski
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 10 May 2018
    • We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the… Continue Reading