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  • Bernard R. Neustadt, Jinsong Hao, +12 authors Kung-I Feng
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 March 2007
  • Antagonism of the adenosine A2A receptor offers great promise in the treatment of Parkinson's disease. Employing the known pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonist SCH 58261 asContinue Reading
  • Ling Tong, Wensheng Yu, +29 authors Joseph A. Kozlowski
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 12 January 2017
  • We describe the research that led to the discovery of compound 40 (ruzasvir, MK-8408), a pan-genotypic HCV nonstructural protein 5A (NS5A) inhibitor with a "flat" GT1 mutant profile. This NS5AContinue Reading
  • Cecilie Maria Madsen, Kung-I Feng, +4 authors Thomas Rades
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences…
  • 1 January 2018
  • ABSTRACT The composition of the human intestinal fluids varies both intra‐ and inter‐individually. This will influence the solubility of orally administered drug compounds, and hence, the absorptionContinue Reading
  • Michel R. Corboz, Maria A. Rivelli, +18 authors John A. Hey
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 April 2011
  • We define the pharmacological and pharmacokinetic profiles of a novel α(2C)-adrenoceptor agonist, compound A [N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-benzoxazin-6-yl]-N-ethyl-N'-methylurea].Continue Reading
  • Wensheng Yu, Ling Tong, +22 authors Joseph A. Kozlowski
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 10 May 2018
  • We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around theContinue Reading