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Validation of ethnomedicinal potential of Tinospora cordifolia for anticancer and immunomodulatory activities and quantification of bioactive molecules by HPTLC.
TLDR
The pharmacological evaluation of extract, fractions and pure molecules revealed the ethnomedicinal value of T. cordifolia for anticancer and immunomodulatory activities. Expand
Defining specific allergens for improved component-resolved diagnosis of shrimp allergy in adults.
TLDR
The lack of standardised shrimp allergens and inadequacy of current extracts for shrimp allergy diagnosis is highlighted by this study, which highlights the need for comprehensive knowledge of less studied allergens to improve diagnostic accuracy. Expand
Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats.
TLDR
Investigation of the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine-induced hepatocellular carcinoma in rats found it to be better suppression of DENA-induced HCC in contrast toCurcumin per se. Expand
Picrorhiza kurroa Enhances β-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked β-Cell Damage in Rats
TLDR
Results showed that P. kurroa rhizome displayed β-cell regeneration with enhanced insulin production and antihyperglycemic effects and improves hepatic and renal functions against oxidative damage. Expand
Critical evaluation of challenges and future use of animals in experimentation for biomedical research
TLDR
This review deals with challenges like poor experimental design and ethical concerns and discusses key concepts like sample size, statistics in experimental design, humane endpoints, economic assessment, species difference, housing conditions, and systematic reviews and meta-analyses that are often neglected. Expand
Bioactive isoquinoline alkaloids from Cissampelos pareira†
TLDR
Seasonal variation study revealed higher content of these compounds during the rainy season, and hayatinine was found to be most active against KB and A549, while, cycleanine against KB cells. Expand
House dust mite allergen causes certain features of steroid resistant asthma in high fat fed obese mice
TLDR
It is speculated that the steroid resistance seen in human obese asthmatics could be stemming from altered NO metabolism and its induced airway remodeling and with further investigations, it would encourage new treatments specific to obese‐asthma phenotype. Expand
A Comprehensive Review on Natural Bioactive Compounds and Probiotics as Potential Therapeutics in Food Allergy Treatment
TLDR
A brief overview of the immune mechanisms underlying food allergy and allergen-specific immunotherapy is provided, followed by a comprehensive collection of current studies conducted to investigate the therapeutic applications of natural compounds and probiotics, including discussions of their mode of action and immunological aspects of their disease-modifying capabilities. Expand
Cytotoxic agents for KB and SiHa cells from n-hexane fraction of Cissampelos pareira and its chemical composition
TLDR
In vitro study of the extract and isolated molecules against KB and SiHa cell lines revealed oleanolic acid and oleic acid as potent cytotoxic molecules with potential anticancer activity. Expand
Water Buffalo (Bubalus bubalis) as a spontaneous animal model of Vitiligo
TLDR
It is reported that acquired depigmentation in water buffalo recapitulates molecular, histological, immunohistochemical, and ultrastructural changes observed in human vitiligo and hence could be used as a model to study Vitiligo pathogenesis and facilitate the discovery and evaluation of therapeutic interventions for vitiliga. Expand
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