It has been reported that the composition of human gut microbiota changes with age; however, few studies have used molecular techniques to investigate the long-term, sequential changes in gut microbiota composition. In this study, we investigated the sequential changes in gut microbiota composition in newborn to centenarian Japanese subjects. Fecal samples… (More)
PURPOSE Previously, a 44 bp insertion in exon 2 of retinitis pigmentosa GTPase interacting protein 1 (RPGRIP1) was identified as the cause of cone-rod dystrophy 1 (cord1), a recessive form of progressive retinal atrophy (PRA) in the Miniature Longhaired Dachshund (MLHD), a dog model for Leber congenital amaurosis. The cord1 locus was mapped using MLHDs from… (More)
Cone-rod dystrophy (CRD) is a form of inherited retinal degeneration (RD) causing blindness in man as well as in several breeds of dog. Previously, a 44 bp insertion in RPGRIP1 (retinitis pigmentosa GTPase regulator interacting protein-1) was associated with a recessive early-onset CRD (cone-rod dystrophy 1, cord1) in a Miniature longhaired dachshund (MLHD)… (More)
PURPOSE We studied whether pupil size affects the flicker electroretinograms (ERGs) recorded by RETeval, a new mydriasis-free full-field flicker ERG system. METHODS We studied 10 healthy subjects. The RETeval manufacturer claims that the system delivers a constant flash retinal illuminance by adjusting the flash luminance to compensate for changes in the… (More)
BACKGROUND Unilateral retinitis pigmentosa is a retinal dystrophy affecting only one eye, the fellow eye being affected neither functionally nor in fundus appearance. There are relatively few cases of unilateral retinitis pigmentosa being followed for more than 5 years. CASE An 18-year-old woman complaining of blurred vision of left eye was found to have… (More)
We examined the regional distributions of atrial natriuretic polypeptide (ANP) and digoxin-like immunoreactivity (DLI) in dog brain, using specific radioimmunoassay. The molecular form of the dog brain ANP was similar to that of alpha-hANP, in gel filtration and reversed-phase HPLC. Distribution of ANP in dog brain differed from rat brain. A significant… (More)
The responses of Ca-dependent action potentials to premature stimulation were studied in the isolated canine ventricular muscle. When very premature stimuli were applied, supernormally augmented responses with propagation occurred, while responses with long preceding intervals were small and not conducted.
Congenital stationary night blindness (CSNB) is a non-progressive, clinically and genetically heterogeneous disease of impaired night vision. We report a naturally-occurring, stationary, autosomal recessive phenotype in beagle dogs with normal daylight vision but absent night vision. Affected dogs had normal retinas on clinical examination, but showed no… (More)
BACKGROUND Papillary thyroid carcinoma often has lymph node metastasis, compared with follicular thyroid carcinoma. The study showed that epithelial-mesenchymal transition occurs in carcinoma cells during the first stage of metastasis, where some extracellular matrix molecules are secreted in large quantities. Sialic acid carried by fibronectin as the… (More)
The purpose of this study is to discuss the mechanism of brain injury experimentally paying attention to the pressure changes on the surface of a brain agar phantom generated by a cavitation.