Kumiko Fujisawa

Learn More
Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 purinoceptors. We find an increase in the numbers of mast cells expressing P2X7 purinoceptors in the colons of(More)
Mast cells (MCs) mature locally, thus possessing tissue-dependent phenotypes for their critical roles in both protective immunity against pathogens and the development of allergy or inflammation. We previously reported that MCs highly express P2X7, a receptor for extracellular ATP, in the colon but not in the skin. The ATP-P2X7 pathway induces MC activation(More)
MafB, a transcription factor expressed selectively in macrophages, has important roles in some macrophage-related diseases, especially in atherosclerosis. In this study, we investigated the mechanism by which hematopoietic-specific MafB deficiency induces the development of obesity. Wild-type and hematopoietic cell-specific Mafb-deficient mice were fed a(More)
Active utilization of museums has attracted attention over the years from the perspective of lifelong learning. However, museum users have various interests and degrees of knowledge. We propose a system of translating explanatory texts about museum collections into iconic expressions by linking the texts to the museum website contents. In this system, the(More)
We propose a methodology to estimate a user’s interest in documents displayed on a computer screen from his or her physical actions. We introduce the ongoing pilot study’s results which showed a possible relationship between face approaches captured by a web camera and the user’s interest in the document on the screen. Some researches showed that physical(More)
  • 1