Kumaravel Rajakumar

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Rickets, a disease of vitamin D deficiency, is rarely confronted by the practicing pediatrician in the United States today. At the turn of the 20th century, rickets was rampant among the poor children living in the industrialized and polluted northern cities of the United States. With the discovery of vitamin D and the delineation of the anti-rachitic(More)
Scurvy, a disease of dietary deficiency of vitamin C, is uncommon today. Among diseases, scurvy has a rich history and an ancient past. The Renaissance (14th to 16th centuries) witnessed several epidemics of scurvy among sea voyagers. In 1747, James Lind, a British Naval surgeon, performed a carefully designed clinical trial and concluded that oranges and(More)
OBJECTIVE To 1) determine if plasma 25-hydroxyvitamin D (25[OH]D) concentrations differ among obese youth with normal glucose tolerance (NGT) versus prediabetes versus type 2 diabetes and 2) assess the relationships between 25(OH)D and in vivo insulin sensitivity and β-cell function in this cohort. RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations(More)
OBJECTIVE To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had(More)
Previous studies have found a high prevalence of vitamin D deficiency in children, yet few validated dietary vitamin D assessment tools are available for use in children. Our objective was to determine whether a short food frequency questionnaire (SFFQ) can effectively assess vitamin D intake in children. Vitamin D intake ascertained by a SFFQ was compared(More)
BACKGROUND The Institute of Medicine (IOM) dietary guidelines for vitamin D are based on limited pediatric data. Our objective was to estimate the dietary vitamin D requirements for maintaining serum 25-hydroxyvitamin D [25(OH)D] concentrations at the various IOM-considered thresholds of vitamin D status (12, 16, and 20 ng/ml) during fall and winter in(More)
OBJECTIVEdTo examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and b-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODSdPlasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had(More)
D concentrations and in vivo insulin sensitivity and b-cell function relative to insulin sensitivity in black and white youth. In the print version of the article listed above, in the " Biochemical Measurements " section, the sentence " The intrassay and interassay coefficients of variation were 8 ng/mL and 10 ng/mL, respectively " should read as follows: "(More)
Malaria has been in existence since ancient times and for millennia thought to be carried by vapors. Alphonse Laveran made the discovery of the malarial parasite in 1880. The next most important milestone in the history of malaria was the unraveling of the mystery of malaria transmission. Ronald Ross, born in British India and educated as a doctor in(More)
A 3-year 9-month-old child presented unresponsive, dehydrated, and in shock, a consequence of child neglect, abuse, and starvation. This scenario provides the vehicle for a discussion of three problems which can be precipitated by child neglect, specifically kwashiorkor, central pontine myelinolysis, and intellectual repercussions of malnutrition.
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