The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection
- H. Traboulsi, Alexandre Cloutier, M. Richter
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 27 July 2015
It is demonstrated that the anti-inflammatory activity of ILG in the context of influenza virus infection is dependent on the activation of the peroxisome proliferator-activated receptor gamma pathway and, interestingly, ILG phosphate (ILG-p)-treated mice displayed decreased lung inflammation.
Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.
- Lok-Hang Yan, Antoine Le Roux, É. Marsault
- Biology, ChemistryEuropean journal of medicinal chemistry
- 2018
Synthesis and Characterization of a Phosphate Prodrug of Isoliquiritigenin.
- Kumaraswamy Boyapelly, Marc-André Bonin, É. Marsault
- Chemistry, BiologyJournal of Natural Products
- 2 March 2017
The synthesis, characterization, solubility, and stability of phosphate prodrug 3 in biological medium in comparison to 1, as well as new results on its anti-inflammatory properties in vivo are reported.
Stereoselective total synthesis of (+)-oploxyne A, (-)-oploxyne B, and their C-10 epimers and structure revision of natural oploxyne B.
- J. Yadav, Kumaraswamy Boyapelly, Sathish Reddy Alugubelli, Srihari Pabbaraja, J. Vangala, Shasi V Kalivendi
- ChemistryJournal of Organic Chemistry
- 17 March 2011
The first total synthesis of recently isolated diacetylene alcohols oPLoxyne A, oploxyne B, and their C-10 epimers was accomplished and the target compounds displayed potent cytotoxicity against neuroblastoma and prostate cancer cell lines.
Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C
- M. Lamontagne Boulet, Charles Isabelle, F. Malouin
- BiologyAntimicrobial Agents and Chemotherapy
- 2 April 2018
Using genomic analysis of in vitro-generated TO-resistant S. aureus strains to identify mutations in genes involved in resistance, the bacterial ATP synthase was identified as the cellular target and the identity of the cellulartarget was validated.