• Publications
  • Influence
Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor.
The constitutive androstane receptor (CAR) is a key sensor in xenobiotic detoxification and endobiotic metabolism. Increasing evidence suggests that CAR also plays a role in energy metabolism byExpand
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Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors.
Darmstoff describes a family of gut smooth muscle-stimulating acetal phosphatidic acids initially isolated and characterized from the bath fluid of stimulated gut over 50 years ago. Despite similarExpand
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Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents.
Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a. cat's claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatoryExpand
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Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2
  • L. Chen, Le Chen, +8 authors L. Yu
  • Chemistry, Medicine
  • Acta pharmaceutica Sinica. B
  • 8 January 2019
Renal cell carcinoma (RCC) is one of the most common malignant tumors affecting the urogenital system, accounting for 90% of renal malignancies. Traditional chemotherapy options are often theExpand
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Inhibition of histone deacetylase 7 reverses concentrative nucleoside transporter 2 repression in colorectal cancer by up‐regulating histone acetylation state
The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside‐derived drugs. Therefore, it is important both physiologically and pharmacologically.Expand
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Thermoresponsive polymers and their biomedical application in tissue engineering - a review.
Thermoresponsive polymers hold great potential in the biomedical field, since they enable the fabrication of cell sheets, in situ drug delivery and 3D-printing under physiological conditions. In thisExpand
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Neochamaejasmin B increases the bioavailability of chamaechromone coexisting in Stellera chamaejasme L. via inhibition of MRP2 and BCRP.
  • L. Pan, Kui Zeng, +5 authors S. Zeng
  • Chemistry, Medicine
  • International journal of pharmaceutics
  • 30 December 2015
Chamaechromone and neochamaejasmin B (NCB) are the most abundant components in the dried roots of the toxic perennial herb Stellera chamaejasme L. and have pharmacological activities. The objectiveExpand
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5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro.
  • X. Lin, Y. Du, +4 authors Jie Zhou
  • Medicine
  • International journal of obstetric anesthesia
  • 1 February 2015
BACKGROUND 5-HT3 receptor antagonists are effective antiemetics for perioperative use. However, their effects on myometrial contractility remain unknown. We examined whether three different 5-HT3Expand
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Recent Advances in Artificially Sulfated Polysaccharides for Applications in Cell Growth and Differentiation, Drug Delivery, and Tissue Engineering
Artificially sulfated polysaccharides, as the mimetics of native heparin and heparan sulfate, are important bioactive compounds, since they show great potential for tuning crucial biologicalExpand
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