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BACKGROUND Congenital heart disease (CHD) is one of the most prevalent birth defects. Housing renovations are a newly recognized source of indoor environmental pollution that is detrimental to health. A growing body of research suggests that maternal occupational exposure to renovation materials may be associated with an increased risk of giving birth to(More)
BACKGROUND Previous studies have shown an inconsistent time trend on the prevalence of anotia and microtia. Little has been reported on the epidemiologic characteristics of anotia and microtia in the Chinese population. METHODS Data from 1996-2007 were obtained from the Chinese Birth Defects Monitoring Network in China. Birth prevalence of anotia and(More)
OBJECTIVE This study aims to evaluate the association between folic acid (FA) supplementation and congenital heart defects (CHDs). METHODS This hospital-based case-control study initiated in 2010 in China analyzed 358 cases and 422 controls. The adjusted odds ratio (AOR) calculated using a logistic model was used to assess the association between FA(More)
BACKGROUND In the past two decades, the under-5 mortality rate in China has fallen substantially, but progress with regards to the Millennium Development Goal (MDG) 4 at the subnational level has not been quantified. We aimed to estimate under-5 mortality rates in mainland China for the years 1970 to 2012. METHODS We estimated the under-5 mortality rate(More)
BACKGROUND Previous studies on the mortality rate of omphalocele are limited. The risk of death of non-isolated omphalocele and that of cases of omphalocele that are diagnosed prenatally by ultrasound are unclear. This study aimed to estimate the perinatal mortality of pregnancies with omphalocele. This study also examined the potential risk of death of(More)
BACKGROUND Maternal smoking during pregnancy has been consistently associated with an increased risk of congenital heart defects (CHDs). However, few studies have reported the association between paternal smoking during pregnancy and CHDs among offspring. This report presents the first case-control study to investigate the possible association between(More)
BACKGROUND Very little is known about the burden and determinants of stillbirths in China. We used data from a national surveillance system for health facility births to compute a stillbirth rate representative of all facility births in China and to explore sociodemographic and obstetric factors associated with variation in the stillbirth rate. METHODS We(More)
Congenital heart defects (CHDs) arise through various combinations of genetic and environmental factors. Our study explores how polymorphisms in the glutathione S-transferase (GST) genes affect the association between cigarette smoke exposure and CHDs. We analysed 299 mothers of children with CHDs and 284 mothers of children without any abnormalities who(More)
BACKGROUND Little is known about secular trends and seasonal variation in the birth prevalence of omphalocele in China. This study aimed to explore the long-term trends and seasonality of this birth defect, to provide insight into the etiology and prevention of omphalocele. METHODS A retrospective analysis of all births with omphalocele (1322 cases in 8.8(More)
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