Learn More
Adolescence is marked by profound psychological and neuroendocrine changes. Cognitive functions that depend on the prefrontal cortex and dopamine (DA), such as decision making, are acquired or refined during adolescence; yet, little is known about how neural circuits mature in the transition to adulthood. Here, we conducted electrophysiological recordings(More)
Norepinephrine (NE) is released in the neocortex after activation of the locus coeruleus of the brain stem in response to novel, salient, or fight-or-flight stimuli. The role of adrenergic modulation in sensory cortices is not completely understood. We investigated the possibility that NE modifies the balance of inhibition acting on 2 different(More)
BACKGROUND A neonatal ventral hippocampal lesion (NVHL) induces behavioral and physiological anomalies mimicking pathophysiological changes of schizophrenia. Because prefrontal cortical (PFC) pyramidal neurons recorded from adult NVHL rats exhibit abnormal responses to activation of the mesocortical dopaminergic (DA) system, we explored whether these(More)
  • Chanalee Hocharoen, Michael T Orr, Lynn C Westley, Chairperson Krebs, Provost, Elizabeth W Fischer +3 others
  • 2014
Adolescence is a developmental period associated with high rates of risk behavior, such as drug experimentation, that can alter neuronal development. The prefrontal cortex (PFC), an area of the brain functional in executive functions, can be affected by drug experimentation. Adolescent drug use has been associated with deficient PFC inhibition in adulthood,(More)
  • 1