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Proto-Oncogene Raf-1 as an Autoantigen in Meniere's Disease
The 28 kd protein extracted from the guinea pig inner ear membranous fraction, which reacted with sera from patients with Meniere's disease, has been subjected to microsequencing. Nineteen aminoExpand
Antibodies against Inner-Ear Proteins in the Sera of Patients with Inner-Ear Diseases
Sera from patients with various inner-ear diseases, especially Meniere’s disease, were investigated by Western blot against guinea pig inner-ear proteins. Of 45 patients, 24 (53%) with various inner-e
Murine Model of Autoimmune Hearing Loss Induced by Myelin Protein P0
Myelin protein P0 has been identified as an autoantigen in inner ear diseases. In order to study autoimmune hearing loss, we performed brain stem auditory-evoked potential (BAEP) studies onExpand
Oral Administration of Collagen Conjugated with Cholera Toxin Induces Tolerance to Type II Collagen and Suppresses Chondritis in an Animal Model of Autoimmune Ear Disease
B10.RIII (H-2r) mice were orally administered cyanogen bromide peptide 11 (CB 11) or cholera toxin B (CTB)–conjugated CB 11 to induce tolerance in collagen-induced autoimmune ear disease. OralExpand
Successful Prevention of Retrocochlear Hearing Loss in Murine Experimental Allergic Encephalomyelitis with T Cell Receptor Vβ8–Specific Antibody
Experimental allergic encephalomyelitis is an animal model of a T cell—mediated autoimmune disease — for example, multiple sclerosis. We demonstrated that mice with experimental allergicExpand
Brain Stem Auditory-Evoked Potentials of Mice with Experimental Allergic Encephalomyelitis
Experimental allergic encephalomyelitis (EAE) is an experimental model for multiple sclerosis. In order to study autoimmune retrocochlear hearing loss, we performed brain stem auditory-evokedExpand
Clonal Expansion of T-Cell Receptor Beta Gene Segment in the Retrocochlear Lesions of EAE Mice
It has been reported that the T cell receptor Vβ8.2 (TcrbV8.2) gene segment is predominantly expressed in encephalomyelitic T cells responding to myelin basic protein (MBP) in experimental allergicExpand
Antigene d'une maladie auto-immune de l'oreille interne et dosage diagnostique
L'invention concerne un antigene 28 kD present dans la structure membraneuse de l'oreille interne et une methode d'immunodosage permettant de diagnostiquer la maladie de meniere, en utilisantExpand