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Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G
The human APOBEC3G (apolipoprotein B messenger-RNA-editing enzyme, catalytic polypeptide-like 3G) protein is a single-strand DNA deaminase that inhibits the replication of human immunodeficiencyExpand
An extended structure of the APOBEC3G catalytic domain suggests a unique holoenzyme model.
Human APOBEC3G (A3G) belongs to a family of polynucleotide cytidine deaminases. This family includes APOBEC1 and AID, which edit APOB mRNA and antibody gene DNA, respectively. A3G deaminatesExpand
Methylation of Structured RNA by the m6A Writer METTL16 Is Essential for Mouse Embryonic Development
Summary Internal modification of RNAs with N6-methyladenosine (m6A) is a highly conserved means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark on thousands ofExpand
Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G
ABSTRACT APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd),Expand
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway
Summary PIWI-interacting RNAs (piRNAs) guide PIWI proteins to suppress transposons in the cytoplasm and nucleus of animal germ cells, but how silencing in the two compartments is coordinated is notExpand
Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries
Small RNAs called PIWI -interacting RNAs (piRNAs) are essential for transposon control and fertility in animals. Primary processing is the small RNA biogenesis pathway that uses long single-strandedExpand
Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G
APOBEC3G is a single‐strand DNA cytosine deaminase capable of blocking retrovirus and retrotransposon replication. APOBEC3G has two conserved zinc‐coordinating motifs but only one is required forExpand
Heparin Binding Stabilizes the Membrane-bound Form of Cobra Cardiotoxin*
It has been shown previously that the long chain fragments of heparin bind to the β-strand cationic belt of the three-finger cobra cardiotoxin (or cytotoxin, CTX) and hence enhance its penetrationExpand
Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.
Piwi-interacting RNAs (piRNAs) guide Piwi argonautes to their transposon targets for silencing. The highly conserved protein Maelstrom is linked to both piRNA biogenesis and effector roles in thisExpand
Cyclic Peptide Inhibitors of HIV-1 Capsid-Human Lysyl-tRNA Synthetase Interaction
The human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) plays a critical role in the viral life cycle. The C-terminal domain (CTD) of CA binds to human lysyl-tRNA synthetase (hLysRS), andExpand