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Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population
TLDR
It is suggested, for the first time, that common miRNA variants may not contribute to GBC susceptibility in North Indian population.
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Significant association between toll‐like receptor gene polymorphisms and gallbladder cancer
TLDR
The present study was undertaken to examine the potential association of two polymorphisms in TLR2 and TLR4 genes with gallbladder cancer (GBC) susceptibility.
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Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India
Genetic variants of DNA repair enzymes may lead to genetic instability and contribute to gallbladder (GB) carcinogenesis.
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Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population
TLDR
An association of PTGS2 −1195G>A polymorphism with gallbladder cancer, particularly in patients without gallstones, suggests a direct role of PT GS2 in cancer development.
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Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.
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Caspase‐8 polymorphisms and risk of gallbladder cancer in a Northern Indian population
TLDR
Low penetrance variants in CASP8 gene may alter the susceptibility toward gallbladder cancer, and molecular modeling results of rs1045485 polymorphism indicated that the overall configuration of both wild‐type and polymorphic CASp8 protein were similar, with negligible deviation at the site of the polymorphism itself.
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Missense substitutions in the GAS1 protein present in holoprosencephaly patients reduce the affinity for its ligand, SHH
TLDR
It is demonstrated that sequence variants in GAS1 can impair its physical interaction with SHH, suggesting a decrease in the SHH downstream signaling cascade as a pathogenic mechanism of disease.
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Potential biomarkers in gallbladder cancer: present status and future directions
Context: Carcinoma of the gallbladder (GBC) is the most common biliary tree cancer in the world. Beside gallstones, no specific risk factors for GBC are currently established. Several published…
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Survivin promoter −31G/C (rs9904341) polymorphism and cancer susceptibility: a meta-analysis
TLDR
The present meta-analysis suggests an important role of survivin −31 G/C polymorphism with cancer risk especially in Asian population, however, further studies with larger sample size are required to draw more comprehensive conclusions and provide more precise evidence in individual cancers.
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Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia
TLDR
These results in humans support the notion of DARC null erythroid progenitors preferentially differentiating to myeloid cells, leading to activated DARCnull neutrophils egressing from circulation to the spleen, and causing relative neutropenia.
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