Ksenia L Pisarchuk

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PURPOSE The epidermal growth factor receptor (EGFR) is overexpressed in several tumor types, and its expression is influenced by the length of a 5'-end microsatellite repeat (CA)n: the longer the repeat, the lower the expression. Dinucleotide repeats accumulate insertion/deletion types of mutations in tumors with microsatellite instability. We designed this(More)
Dietary supplied glycine resulted in dose-dependent effects on the growth of experimental animals, on diet-induced thermogenesis and on food efficiency. Furthermore it is possible to influence activities of enzymes involved in glycine metabolism and other enzyme activities in liver tissue by increased glycine supply. Simultaneously, changes occurred in(More)
An indirect method for estimation of the fat percentage in the animal organism, a tritium test, was studied on laboratory male rats aged 4 and 12 months. Results obtained from the tritium test and direct chemical analysis were compared. With age a mean absolute error of the tritium test increased (from 1 to 8%) as against actual values of the water and fat(More)
Aimed to the construction of a prediction equation for estimations of lipid content from animal water content body composition was determined by whole body analysis of male rats (1) given access, ad libitum, to a commercial standard diet (n = 144; ranging from 60 to 600 g in weight, and from the 4th to the 34th week of age), and (2) showing striking(More)
Some indices of aging, metabolism and life span were studied in the male Wistar rats, raised during the suckling period (up to 21 days) in nest of 8-10 pups (control) and 2 pups/dam (experiment). The milk intake of the rat pups was controlled by adjusting litter size at birth. After weaning, the rats of both groups each received the same standard diet ad(More)
Age-dependent features of protein synthesis intensity were studied in tissues (liver, muscles, plasma) by the method of continuous constant L-(1-14C)-leucin infusion. The investigation was conducted in male rats aged 4 and 24 months that were bred in large and small holes, and received rations with varying protein content (2.5, 15 and 60% of casein). It has(More)
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