Krzysztof Woźniczka

Learn More
OBJECTIVES The experience with bone marrow transplantation (BMT) from matched unrelated donors (MUD) for paroxysmal nocturnal hemoglobinuria (PNH) is limited and optimal preparative regimen has been not established. METHODS We report first two MUD BMTs for patients with PNH in Poland. Preparative regimen consisted of Treosulfan, Fludarabine and(More)
OBJECTIVES Chronic graft-versus-host-disease (cGVHD) deteriorates survival and quality of life after allogeneic hematopoietic cell transplantation (alloHCT). We evaluated the incidence and risk factors for this complication based on a single-center experience. METHODS 255 consecutive patients, aged 29 (10-56) years, who survived without disease(More)
Although allogeneic bone marrow transplantation (BMT) has the potential to cure patients with paroxysmal nocturnal hemoglobinuria (PNH), experience with transplantation from matched unrelated donor (MUD) in PNH is limited to five reports describing a total number of 18 transplants with 50% survival (Table 1). The significance of additional(More)
Hairy cell leukaemia (HCL) is a rare, indolent lymphoproliferative disorder characterized by varying degrees of cytopenias and the presence of malignant B cells with cytoplasmic projections. Cladribine (2-chlorodeoxyadenosine, 2-CdA) is an adenosine deaminase-resistant purine analogue and has been shown to be very effective as a first-line therapeutic(More)
The prevalence of JAK2V617F tyrosine kinase mutation differs between various variants of myelofibrosis with the higher detection rate for patients with post-polycythemia vera myelofibrosis (post-PV MF; 91%) if compared to primary myelofibrosis (PMF; 45%) and post-essential thrombocythemia myelofibrosis (post-ET MF; 39%). The impact of V617F point mutation(More)
Clonal T-cells can produce a large amount of Th2-type cytokines, causing chronic hypereosinophilia.Abnormal T-cell clones often bear CD3-CD4+ phenotype, less frequent CD3+CD4-CD8-. T-cell clones with normal T-cell phenotype CD3+CD4+ (or CD8+) were also identified. We report on a patient with peripheral T-cell lymphoma, unspecified (PTCL-U) presenting with(More)
Hairy cell leukemia (HCL) and multiple myeloma (MM) originate from mature B-cell and they are characterized by different clinical symptoms and treatment. Their clinical outcome is also different. The introduction of 2-CdA makes HCL a potentially curable disease, but MM still remains incurable despite a therapeutic progress made in the recent years. We(More)
AIM OF THE STUDY Mutant NPM1 and CEBPA have been reported in patients with acute myeloid leukaemia (AML) and intermediate cytogenetic risk, and they appear to be associated with characteristic demographic and laboratory data, as well as clinical outcome. The objective of the study was to assess the clinical relevance of NPM1 and CEBPA mutations in AML. (More)