Krzysztof S. Gołba

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BACKGROUND The aim of this study was to compare cardiac magnetic resonance imaging (CMR) with 2-dimensional echocardiography (2D echo) in the assessment of left ventricle (LV) function parameters and mass in patients with ischemic heart disease and severely depressed LV function. Although 2D echo is commonly used to assess LV indices, CMR is the(More)
OBJECTIVE The studies showing the superior characteristics of ITA graft and its impact on the clinical results of coronary artery surgery were performed with ITA harvested almost exclusively as a pedicle. This study assesses the impact of ITA skeletonization on its innervation and reactivity. METHODS Segments of skeletonized and non-skeletonized ITA were(More)
OBJECTIVES It remains unclear why some patients with cardiomyopathy secondary to anterior infarction do, and others do not develop functional mitral regurgitation (MR). METHODS Thirty-six patients after anterior infarction with ejection fraction (EF) below 35%, 18 with no/trivial and 18 with moderate/severe MR, underwent cardiac magnetic resonance(More)
C-Terminal dipeptide fragment of tuftsin, Pro-Arg, substituted by D-amino acids, and tuftsin analogs with n-hexyl- and n-heptylamine coupled to their C-termini were synthesized by a classical method in solution and their antinociceptive activity was measured by tail flick immersion test (0.4 microM/icv). D-Pro-D-Arg and D-Pro-L-Arg showed an analgesic(More)
Leu-enkephalin (LENK) injected intracerebroventricularly (icv) in a dose of 50-400 micrograms to male Wistar rats inhibited their open field locomotor activity. This effect was antagonized by 1 microgram icv of ICI 174864 but not by naloxone (NAL). Doses of 5 and 10 micrograms of ICI 174864 icv induced a characteristic abnormal behavioral syndrome, which(More)
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